Introduction to Proteins: Structure, Function, and Motion

Amit Kessel, Nir Ben-Tal

December 17, 2010 by CRC Press
Reference - 654 Pages - 375 B/W Illustrations
ISBN 9781439810712 - CAT# K10533
Series: Chapman & Hall/CRC Mathematical and Computational Biology

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Features

  • Discusses the main experimental and computational methods used today for studying protein structure and dynamics
  • Presents an extensive discussion of the energetics of protein structure
  • Covers intrinsically unstructured proteins to provide a complete and realistic view of the proteome and to explore the full repertoire of protein functions
  • Describes protein–ligand interactions
  • Explores the industrial use of enzymes in protein engineering and the rational design of protein targeting in pharmaceutical drugs
  • Identifies widely used and fully accessible Internet-based resources, such as databases and algorithms
  • Provides downloadable questions for each chapter at www.crcpress.com

Solutions manual and figure slides available upon qualifying course adoption

Summary

As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life.

With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules.

The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines.

This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.