Although GC-MS (gas chromatography-mass spectrometry) finds applications in fields as diverse as the food processing industry, medicine, pharmacology, and environmental analysis, the few works that are dedicated to this use of mass spectrometry are generally highly complex and theoretical. Emphasizing the practical aspects of GC-MS, without neglect
Concepts of Gas Chromatography
General Points
Instrumentation
Fast Chromatography
Multidimensional Chromatography
References
Introduction to Mass Spectrometry: General Points
Mass Spectrometer Components
Vacuum
Detectors
References
Ion Production in GC-MS: Sources
Definitions and General Points
Electron Ionization
Chemical Ionization
References
Ion Separation: Analyzers
General Points
Technical Features
Quadrupoles
Ion Traps
Time-of-Flight Analyzers
Magnetic Analyzers
References
Acquisition Modes in GC-MS
Definitions
Full Scan Analysis
SIR, SIM, and SIS Modes
Tandem Mass Spectrometry (MS/MS)
References
Comparison of Quadrupolar Analyzer Performances: Criteria for Choosing an Analyzer
Comparison Criteria
Spectral Repeatability and Autoprotonation
Response Functions and Limits of Detection
Chromatographic Profiles
Maintenance and Robustness
Choosing a Quadrupolar Analyzer
References
Quantification by GC-MS
Introduction
External Standard Quantification
Internal Standard Quantification
Method Validation
References
Spectra Databases for GC-MS
Limitations of Mass Spectra Interpretation
Spectra Databases
Research Algorithm
Results Display
Research Parameters
Databases and Mass Spectra Interpretation
Other Uses of Databases
References
Introduction to Mass Spectra Interpretation
Introduction
Chemistry Principles Fundamental to Mass Spectra Interpretation
Dissociation Mechanisms and Interpretation of Mass Spectra in Electron Ionization
Dissociation Mechanisms in Positive Chemical Ionization
Dissociation Mechanisms in Negative Chemical Ionization
Mass Spectra Interpretation Strategy
References
Index
Biography
Bouchonnet, Stephane
"Introduction to GC-MS Coupling is a textbook for novices and experienced users, providing practical aspects of GC–MS, without neglecting the fundamental theory. It can be recommended to students, young scientists, and established researchers starting with GC–MS applications."
—Hans H. Maurer, Anal Bioanal Chem, 2013
