1st Edition
Inflammatory Mechanisms in Allergic Diseases
Contains patterns of allergic reactivity for disorders such as asthma, atopic dermatitis, urticaria, and anaphylaxis. Written by leading experts in the field, Inflammatory Mechanisms in Allergic Diseases covers non-anaphylactic drug disorders; synthesis and formation of IgE antibodies; new treatments using allergenic peptides, immunostimulatory oligonucleotides, and pharmacogenomics;recent advances targeting effector mechanisms; hypersensitivity reactions to drugs and more! With over 3100 references, tables, drawings, and micrographs, Inflammatory Mechanisms in Allergic Diseases is an essential reference for allergists, pulmonologists, immunologists, dermatologists, ophthalmologists, otolaryngologists, internists, pediatricians, family practitioners, and medical students in these disciplines.
Part One INTRODUCTION 1. Introduction Part Two COMPONENTS IN THE ALLERGIC INFLAMMATORY RESPONSE 2. Mast Cells and Basophils 3. Eosinophils 4. Neutrophils 5. Lymphocytes 6. Leukocyte-Blood Vessel Interactions 7. Extracellular Matrix 8. The Regulation of IgE Synthesis 9. Effector Roles of IgE Antibodies: Targeting Allergen to the High-Affinity IgE Receptor for Fee RI-Dependent Signaling and Antigen Presentation 10. Lipid Inflammatory Mediators: Leukotrienes, Prostaglandins, Platelet-Activating Factor 11. Cytokines in Allergic InflammationPart Three ALLERGIC INFLAMMATORY MECHANISMS IN CLINICAL DISORDERS 12. Mechanisms of Allergic Rhinitis 13. Nasal Polyps and Sinusitis 14. Allergic Eye Disorders15. Asthma 16. Atopic Dermatitis 17. Urticaria 18. Anaphylaxis and Inflammation 19. Nonanaphylactic Drug Disorders 20. Vasculitis 21. Allergic Bronchopulmonary Aspergillosis, Allergic Fungal Sinusitis, and Hypersensitivity Pneumonitis Part Four EMERGING CONCEPTS IN THE MODULATION OF ALLERGIC INFLAMMATION 22. Pharmacological Approaches 23. Synthetic and Genetically Engineered Allergen Derivatives for Specific Immunotherapy of Type I Allergy 24. Anti-IgE Antibody Therapy 25. Allergen Injection Immunotherapy 26. DNA Immunomodulation of Asthma Part Five OVERALL SUMMARY/CONCLUSIONS 27. Mechanisms of Allergic Disease and the Implications for Therapeutic Interventions
Biography
Burton Zweiman (University of Pennsylvania, Pennsylvania, USA) Lawrence B. Schwartz (Virginia Commonwealth University, Richmond, Virginia, USA)
