1st Edition
Inflammation, Oxidative Stress, and Cancer Dietary Approaches for Cancer Prevention
Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals.
Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics.
The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.
Section I: Inflammation, Oxidative Stress, Nutritional Phytochemicals, and Cancer
Overview on Oxidative Stress, Inflammation, Cancer Initiation/Progression, and How to Prevent Carcinogenesis/Cancer
Jong Hun Lee and Ah-Ng Tony Kong
Overview of Obesity, Inflammation, and Cancer
Ximena Paredes-Gonzalez, Tin Oo Khor, Limin Shu, Constance Lay-Lay Saw, and Ah-Ng Tony Kong
Inflammation-Induced Esophageal and Colon Adenocarcinoma Formation in Animal Models: Mechanisms of Carcinogenesis and Prevention
Chung S. Yang, Xiaoxin Chen, and Guang-Yu Yang
Overview of Common Dietary Phytochemicals Possessing Antioxidant Properties through Nrf2
Limin Shu, Chengyue Zhang, and Ah-Ng Tony Kong
Section II: Signal Transduction, Molecular Targets, and Biomarkers of Dietary Cancer-Preventive Phytochemicals
Signal Transduction and Molecular Targets of Dietary Cancer-Preventive Phytochemicals
Ann M. Bode and Zigang Dong
Biomarkers for Diet in Cancer Prevention Studies
Zheng-Yuan Su, Limin Shu, and Ah-Ng Tony Kong
Section III: In Vivo Absorption and Pharmacokinetics of Nutritional Phytochemicals
Metabolism and Transport of Anticancer and Anti-Inflammatory Phytochemicals across the Gastrointestinal Tract
Yong Ma and Ming Hu
Pharmacokinetics of Dietary Isothiocyanates and Flavonoids
Yoshihiko Ito, Shizuo Yamada, and Marilyn E. Morris
Section IV: Vitamins A, D, and E Cancer Prevention, and Clinical Perspective
Retinoic Acid Signaling in Hematopoiesis and Immune Functions, and Options for Chemoprevention
Rodica P. Bunaciu and Andrew Yen
Vitamin D and Inflammation in Cancer: Emerging Concepts
Katrina M. Simmons, Wei-Lin W. Wang, Martin P. R. Tenniswood, and JoEllen Welsh
Vitamin E Family of Compounds and Cancer Prevention
Kimberly Kline, Weiping Yu, Richa Tiwary, and Bob G. Sanders
The Protective Role of Vitamin E in Inflammation and Cancer
Amanda K. Smolarek and Nanjoo Suh
Vitamin D and Cancer: Research Update and Clinical Recommendations
Kathleen M. Wesa and Barrie R. Cassileth
Section V: Omega-3 and Omega-6 Fatty Acids
Plant and Marine Sources of Omega-3 Polyunsaturated Fatty Acids, Inflammation, and Cancer Prevention
Julie K. Mason, Ashleigh K. A. Wiggins, and Lilian U. Thompson
Polyunsaturated Fatty Acids and Cancer Prevention
Janel Suburu and Yong Q. Chen
Anti-Inflammatory and Proresolving Effects of Docosahexaenoic Acid: Implications for Its Chemopreventive Potential
Young-Joon Surh, Na-Young Song, Ha-Na Lee, and Hye-Kyung Na
Section VI: Flavonoids and Polyphenols
Green Tea and Cancer Prevention
Naghma Khan and Hasan Mukhtar
Curcumin from Turmeric Spice, Anti-Inflammatory and Antioxidant Phytochemical, and Cancer Prevention
Tin Oo Khor and Ah-Ng Tony Kong
Flavonoids: Impact on Prostate Cancer and Breast Cancer
James Cardelli, David Coleman, and Katherine D. Crew
Cancer Prevention by Isoflavone
Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar
Anti-Inflammatory Efficacy of Silibinin: Role in Cancer Chemoprevention
Alpna Tyagi, Gagan Deep, and Rajesh Agarwal
Cancer Prevention by Antioxidant Compounds from Berries
Noah P. Zimmerman, Dan Peiffer, and Gary D. Stoner
Section VII: Garlic Organosulfur Compounds and Crucifer Glucusinolates
Garlic and Cancer Prevention
Chi Chen
Molecular Mechanisms of Cancer Chemoprevention with Benzyl Isothiocyanate
Anuradha Sehrawat and Shivendra V. Singh
Suppression of Prostate Carcinogenesis by Dietary Isothiocyanates
Young-Sam Keum
Section VIII: Selenium, Herbal Medicines, Alpha Lipoic Acid, and Cancer Prevention
Cancer Prevention with Selenium: Costly Lessons and Difficult but Bright Future Prospects
Junxuan Lü, Cheng Jiang, and Jinhui Zhang
Chemoprevention of Lung Cancer by Ginseng
Michael S. You, Lucina C. Rouggly, Ming Hu, Zhen Yang, Ming You, and Yian Wang
Anti-Inflammatory Botanical Dietary Supplements for Women’s Health: Role in Breast Cancer Prevention?
Birgit M. Dietz and Judy L. Bolton
PHY906, a Cancer Adjuvant Therapy, Differentially Affects Inflammation of Different Tissues
Wing Lam, Scott Bussom, Zaoli Jiang, Wei Zhang, Fulan Guan, Shwu- Huey Liu, and Yung-Chi Cheng
Lipoic Acid in the Prevention and Treatment of Inflammatory Disease and Cancer
Kate Petersen Shay, Regis F. Moreau, and Tory M. Hagen
Section IX: Epigenetics and Chronic Inflammation
Epigenetic Modifications by Dietary Phytochemicals in Cancer Prevention
Tabitha M. Hardy and Trygve O. Tollefsbol
Nutritional Phytochemicals and the Management of Chronic Inflammation
Laura Marler and John M. Pezzuto
Biography
Ah-Ng "Tony" Kong, Ph.D., is a distinguished professor (PII), Glaxo Endowed Chair Professor of Pharmaceutics, and director of the Graduate Program in Pharmaceutical Sciences at Rutgers, the State University of New Jersey. He is also the director for the Center for Pharmacogenetics and Pharmacogenomics at Rutgers University. Dr. Kong has published more than 200 original research papers, review articles, and book chapters. He has chaired and given presentations in many national and international symposia and conferences and is currently serving on the board of 15 international journals. His research areas are in dietary phytochemicals (signaling and gene expression, nutrigenomics, cancer chemoprevention); animal tumor models of the prostate, colon, and skin; epigenetics/epigenomics; oxidative/redox/inflammatory stress response; Nrf2-mediated nuclear transactivation and signaling; and pharmacokinetics and pharmacodynamics of phytochemicals.
