First published in 1989, Immunology of Nude Mice presents a discussion of the nature of this viable laboratory mutant. This new volume updates all immunological information contained in the sparse literature concerning nude mice. It comprehensively explores some of the fre-quent questions associated with nude mice, such as if the mutant is really athymic or if the thymic defect causes all of the other deviations from brain to gonads. The practical consequences of hairlessness of the mutant are also consid-ered. Illustrated with original photographs and tables doc-umenting novel facts in immunology and physiology of nude mice, this publication is valuable for investigators and stu-dents entering the field.
Table of Contents
Introduction: The Contradictory Mouse. The Nude Mutation. The Thymic Defect. T Cells. B Cells and Im-munoglobulins. Stem Cells and Connective Tissues. Phagocytic Systems and Native Resistance. Lymphatic Tissues and Cellu-lar Immune Reactions. Hairlessness and Metabolic Compensa-tions. Neuroendocrine Regulations. Nude Gene Transfers and Remutation. Conclusions. Index. 184 pp., 7x10, 1988, ISBN 0-8493-6662-3.