A comprehensive review of the literature on steroid hormone receptor immuncytochemistry. It includes the development of the first monoclonal antireceptor antibody and initial procedures designed to localize steroid receptors in situ up to the present. The step-by-step instructions provide easy reading of topics such as tissue handling, processing, and interpretation. This text places particular emphasis on the studies of human material-especially mammary carcinoma. It presents specific details with chapters on estrogen and progesterone receptors in breast malignancies and benign breast disease. Each section of this outstanding book contains comprehensive photomicrographs that illustrate the most salient features discussed. Detailed graphs pertaining to theoretical particulars concerning technology and the relationship between image analysis and endocrine response are also included. This monograph is an excellent resource for all researchers concerned with hormone-dependent tissues, pathologists who have an interest in working with novel techniques for localizing steroid hormone receptors, and oncologists who must use assay results in the treatment of breast cancer.
Table of Contents
Introduction. Immunocytochemical Assay of Estrogen Receptors in Breast Cancer. A Review of the Literature. Technique for Performance of the Immunocytochemical Steroid Receptor Assay. ERICA and PgRICA in Breast Diseases: The SUNY Health Science Center Experience (Part One). Progesterone Receptors in Breast Cancer. Significance, Literature Review, and SUNY Health Science Center Experience (Part Two). Microscopic Imaging of Steroid Receptors: A Critical Review of Methodology and Imaging Strategies. Receptogram Analysis: Endocrine Response Prediction in Breast Cancer by Steroid Receptor Imaging. Immunocytochemistry of Steroid Hormone Receptors in the Female Reproductive System. Steroid Receptors in the Cardiovascular Tree by Immunocytochemistry. Immunohistochemical Identification of Estrogen and Progesterone Receptors in the Thyroid and Pancreas.