1st Edition

Immune Mechanisms in Allergic Contact Dermatitis

By Andrea Cavani Copyright 2005

    This book presents an overview of the pathogenesis of allergic contact dermatitis (ACD). It explains the characterization of T cell subsets which modulate immune reaction to chemicals and may represent a formidable tool for new therapeutic approaches to ACD and other T cell-mediated skin disorders.

    1. Approaches to the Predictive Identification and Assessment of Chemical Contact Allergens 2. Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Recepto 3. Langerhans Cell Migration and the Induction Phase of Skin Sensitization 4. Contribution of CD4' and CD8' T Cells in Contact Hypersensitivity and Allergic Contact Dermatitis 5. T Cell Subsets in Allergic Contact Dermatitis 6. T Cell Recruitment in Allergic Contact Dermatitis 7. Cytokines in Contact Sensitivity 8. The Use of Gene-Targeted Mice in Contact Hypersensitivity Research 9. A Dual Role for Mast Cells in Contact Hypersensitivity Reactions: More Team Players in Type 1 T Cell Mediated Contact Hypersensitivity Reactions 10. Multiple Roles of Keratinocytes in Allergic Contact Dermatitis 11. UVB Radiation and Modulation of T Cell Responses to Haptens 12. Dendritic Cells as a Target for Therapeutic Intervention of Contact Hypersensitivity 13. Evidence-Based Answers to Clinical Questions in Allergic Contact Dermatitis

    Biography

    Cavani, Andrea