and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations.
This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data.
This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Table of Contents
Summary and Recommendations, David A. Neumann and Carole A. Kimmel
Accounting for Variability in Responsiveness in Human Health Risk Assessment, Jean A. Grassman, Carole A. Kimmel, and David A. Neumann
Strategies for Assessing Human Variability in Susceptibility and Using Variability to Infer Human Risks, Dale Hattis
Interindividual Variability in Neurotoxicity, David A. Eckerman, John R. Glowa, and W. Kent Anger
Variability in Human Response to Reproductive and Developmental Toxicity, Anthony R. Scialli and Armand Lione
Risk Assessment of the Effects of Ozone Exposure on Respiratory Health: Dealing with Variability in Human Responsiveness to Controlled Exposures, Philip A. Bromberg
Host-Environment Interactions That Affect Variability in Human Cancer Susceptibility, L.T. Frame, C.B. Ambrosone, F.F. Kadlubar, and N.P. Lang
Genetic Susceptibility and Cancer Risk, Neil Caporaso and Nathaniel Rothman
Human Variability in Susceptibility and Response: Implications for Risk Assessment, David A. Neumann and Carole A. Kimmel
"These eight chapters, reflecting the contributions and insights of scientists from academia, industry, and government, offer a state-of-the-science assessment of how we characterize and quantify human variability and how that information might influence current thinking about risk assessment."
- Alex Malaspina, President, International Life Sciences Institute, from the Foreword
"This edited volume addresses an important and timely issue, namely how variability in human susceptibility to disease should be reflected in environmental risk assessment... it provides a wealth of information useful for academics, researchers and practioners in the field of risk assessment. For the statistician interested in methodology related to risk assessment, the volume can provide invaluable insight into the way toxicologists and risk assessors think about population versus individual risk and susceptibility... this provocative book can generate many interesting new ideas and provides perfect fodder for creative thinking on new statistical methodology for environmental risk assessment."
- Statistics in Medicine, vol. 20, no. 14, July 2001