Human Growth Hormone Pharmacology: Basic and Clinical Aspects

1st Edition

Kathleen T. Shiverick, Arlan L. Rosenbloom

CRC Press
Published March 9, 1995
Reference - 192 Pages
ISBN 9780849383847 - CAT# 8384
Series: Handbooks in Pharmacology and Toxicology

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Summary

This book addresses a wide range of basic and clinical issues in the physiology and pharmacology of growth hormone. The volume is organized like a textbook. It begins with factors contributing to GH gene expression, the functional relationships of the GH receptor, molecular biological analysis of the GH-GH receptor complex and proceeds to describe the insulin-like growth factor axis. Transgenic models are discussed for analysis of discrete effects. These discussions provide a bridge to clinically oriented discussions of growth abnormalities in GH deficient children, GH insensitivity due to deficiency of the GH receptor, and the concept of aging as a GH/IGF-I deficiency state. Discussions also include the immune system as a source and a responder to GH, GHRH, IGF-I and the effects of GH excess.

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