Exploring the most current methods of exposure identification and analysis, this source offers strategies to incorporate developmental neurotoxicity data into the risk assessment processsupplies techniques to enhance and strengthen exposure and endpoint testing and correctly approach data collection and utilizationcompares animal and human endpoint assessmentsdiscusses emerging issues such as endocrine disruptors and pesticides, and the application of neuroimaging techniques in neurotoxicological studiesincludes a survey of alternative statistical methods to derive 'points of departure' for the development of exposure standards.
This reference describes the most recent developments in the design, execution, and interpretation of human developmental neurotoxicology studies. Assessing critical issues and controversies in the field, this guide focuses on dose-response/effect relationships and explores challenges in the measurement of exposure to different types of chemicals, including selected metals, organic pollutants, pesticides, and recreational and therapeutic drugs.
Table of Contents
Introduction. Lead. Alcohol. EMERGING STORIES: OUTSTANDING ISSUES AND DATA NEEDS. PART A: ENVIRONMENTAL CHEMICALS. Methylmercury. Polychlorinated Biphenyls. Solvents. Pesticides. PART B: MEDICINALS. Retinoids.. Chemotherapeutic Drugs. PART C: RECREATIONAL SUBSTANCE USE. Maternal Smoking During Pregnancy and ETS. Cocaine. IMPROVING THE ASSESSMENT OF THE RELATIONSHIPS BETWEEN EXPOSURE AND CLINICAL DISEASE: DATA AND METHODS NEEDS. PART 1: EXPOSURE ASSESSMENT AND PHARMACOKINETIC MODELS. . Metals. Pesticides. Drugs of Abuse.. PART 2: ENDPOINT ASSESSMENT. Parallels Between Animal and Human Models of Nerobehavioral Disorders: General Considerations. Neuropsycchological Assessment Issues and Strategies. Role of Neuroimaging. Childhood Exposures and Adult Disease. PART 3: DATA ANALYSIS AND DEFINING BASES OF INDIVIDUAL SUSEPTIBILITY.. The Experimentalist Perspective. Applications of Structural Equation Modeling.. The Social-Ecological Perspective. Molecular Mechanisms.. PART 4: INCREASING THE RELEVANCE AND UTILITY OF DATA FROM DEVELOPMENTAL NEUROTOXICITY STUDIES TO CLINICAL PRACTICE AND TO RISK ASSESSMENT. Ethical Considerations. The Political and Economic Contexts.. Clinician Perspective. Public Health Perspective.