The existence of multiple sulfotransferases (SULTS) was first discovered in 1958. Since then, any attempts to create a comprehensive text dedicated to sulfation and sulfotransferases have been rare and, thanks to rapid advances in molecular biology and biochemistry, quickly outdated. However, those advances have permitted an accelerated understanding of human sulfotransferase activity and with it the creation of a growing database on sulfotransferases that, until now, has remained scattered in the literature.
Human Cytosolic Sulfotransferases serves an important function by the mere feat of culling the information from the literature to present an up-to-date summary of the field. Fortunately, the editors have gone a step further in providing us with a multidisciplinary overview of human sulfotransferases, covering not only basic biochemistry, genetics, and molecular biology, but also exploring current clinical uses involving pharmacology, enzymology, and environmental toxicology.
The book's thirteen chapters, written by some of the most renowned scientists in the field, address the huge diversity of topics that are impacted by sulfation. Included are discussions that move from general nomenclature and structure to molecular cloning of human cytosolic sulfotransferases, and sulfate conjugation in pharmocogenetics and pharmacogenomics. Entire chapters focus on sulfotransferases in the human fetus and neonate, sulfation of thyroid hormones, as well as estrogen sulfotransferases in breast cancer and the activation/inactivation of carcinogens and mutagens by human sulfotransferases.
Table of Contents
Nomenclature and Molecular Biology of the Human Sulfotransferase Family, Rebecca L. Blanchard
Structure and Function of Sulfotransferases, Jyrki Taskinen and Michael W.H. Coughtrie
PAPS and Sulfoconjugation, Nancy B. Schwartz
Sulfate Conjugation: Pharmacogenetics and Pharmacogenomics, Richard M. Weinshilboum, and Araba A. Adjei
Molecular Cloning of the Human Cytosolic Sulfotransferases, Charles N. Falany, Connie A. Meloche, Donging He, and Josie L. Falany
Sulfotransferases in the Human Fetus and Neonate, Emma L. Stanley, Robert Hume, and Michael W.H. Coughtrie
Sulfation of Thyroid Hormones, Monique H.A. Kester, Michael W.H. Coughtrie , and Theo J. Vissor
Estrogen Sulfotransferase in Breast Cancer, Jorge R. Pasqualini and Gerard S. Chetrite
Sulfation of Drugs, Gian Maria Pacifici
Human SULT1A Sulfotransferases, Nadine Hempel, Amanda Barrett, Niranjali Gamage, Ronnald G. Duggleby, Kelly F. Windmill, Jennifer L. Martin, and Michael E. McManus
Hydroxysteroid Sulfotransferases SULT2A1, SULT2B1a and SULT2B1b, Charles A. Strott
Species Differences in Cytosol Sulfotransferases, Kiyoshi Nagata, Miki Shimada, and Yasushi Yamazoe
Activiation and Inactivation of Carcinogens and Mutagens by Human Sulfotranserases, Hansruedi Glatt