Histologic Basis of Mouse Endocrine System Development: A Comparative Analysis

Matthew Kaufman, Alexander Yu. Nikitin, John P. Sundberg

October 15, 2009 by CRC Press
Reference - 240 Pages - 102 Color Illustrations
ISBN 9781420088182 - CAT# 88181
Series: Research Methods For Mutant Mice


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As the first substantial study of mouse endocrine systems, Histologic Basis of Mouse Endocrine System Development:

  • Integrates historical perspectives of embryogenesis of the endocrine system between many species, but primarily between humans and mice
  • Aids in the analysis of genetically engineered mice with embryonic abnormalities
  • Provides representative images are in the text for orientation and reference
  • Contains more than 100 high-magnification color plates organized in folders by organ name.
  • Includes scanned serial sections of embryos at defined stages of post conception
  • Illustrates similarities and differences between the mouse endocrine system and that of other species


Transform Your Computer Monitor into a Virtual Microscope

The world’s leading expert on mouse embryology, Dr. Matthew Kaufman is responsible for producing classic texts that are considered the most respected in the field. While the quality of their photowork at the time was considered state-of-the-art, the technology available when the books were produced limited the original printed pages to black-and-white photomicrographs and line diagrams, which are too small and not detailed enough to meet the requirements of today’s mouse pathologists who demand high resolution, high detailed full color slides.

Meeting this need and going beyond, Histologic Basis of Mouse Endocrine System Development:A Comparative Analysis not only offers upgraded slides but actually turns your computer into a virtual microscope that researchers from just a few short years ago could have only dreamt about.

Working in conjunction with Dr. Nikitin and Dr. Sundberg, Dr. Kaufman has scanned the finest images from his previous collections and then using modern graphic technology has elevated the quality to levels not seen before. By installing the ImageScope™ software (Aperio Technologies, Inc.) and graphics from the accompanying DVD, readers will be able to turn their computers into virtual microscopes. Operating their computers like cutting-edge diagnostic tools, they can move the image from the glass microscope across the screen and enlarge areas of interest for more detailed evaluation. This tool allows them to look at specific organs or structures at various magnifications at different stages of embryogenesis, helping to identify structures in normal mouse embryos and providing a comparison for those embryos under investigation.

While the emphasis of this one-of-a-kind book is on comparative embryology of the endocrine organs, the embryonic images at various developmental stages contain many other organs. It provides a series of representative figures that display the histological features of hematoxylin- and eosin-stained sections of the various endocrine organs at sequential stages of their development in the mouse.

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