Vulnerable plaque development is the result of a complex series of molecular and cellular events involving inflammation, apoptosis, rupture, and thrombosis. A detailed understanding of the mechanisms underlying the development of high-risk plaques, along with the ability to visualize and diagnose these vulnerable lesions, will lead to the effective management of acute coronary syndromes.
High-Risk Atherosclerotic Plaques: Mechanisms, Imaging, Models, and Therapy brings together timely, in-depth reviews by renowned international cardiologists and scientists. Chapters cover the definition, structure, and cellular and molecular mechanisms of high risk plaque development, as well as animal models of vulnerable plaque, plaque imaging, and current and future therapies. Medical experts discuss intravascular ultrasound, optimal coherence tomography, magnetic resonance imaging, and coronary thermography. The final chapter reviews both current and future local and systematic strategies for the therapeutic management of vulnerable plaque.
Exploring all aspects of this primary cause of acute coronary syndromes, this informative book updates our knowledge on the detection and treatment of vulnerable plaques. It is a valuable resource that can greatly advance the progress in treatment and prevention.
Table of Contents
Foreword, Levon M. Khachigian
Cellular and Molecular Mechanisms of Plaque Rupture, Prediman K. Shah
Apoptosis and Plaque Vulnerability, Martin R. Bennett
Animal Models of Vulnerable Plaque, Harry C. Lowe, Levon M. Khachigian, Leonard Kritharides, and Jason L. Johnson
Diagnosis of Vulnerable Plaques in the Cardiac Catheterization Laboratory, Johannes A. Schaar, Evelyn Regar, Chourmouzios A. Arampatzis, Cornelis J. Slager, Frank J. Gijsen, Jolanda J. Wentzel, Pim J. de Feyter, A.F.W. van der Steen, and Patrick W. Serruys
Imaging of the High Risk Atherosclerotic Plaque by Intravascular Ultrasound: Focal Assessment of Morphology and Vulnerability or Systemic Assessment of Disease Burden and Activity? Paul Schoenhagen, Richard D. White, and Steven E. Nissen
Optical Coherence Tomography for Detection of Vulnerable Plaque, Fabian Moselewski, Stephan Achenbach, and Ik-Kyung Jang
Magnetic Resonance Imaging of "High Risk" Plaque, Stephen G. Worthley and Juan J. Badimon
Nuclear Imaging of the Vulnerable Plaque: Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET), John Davies, James Rudd, Tim Fryer, Jonathan Gillard, and Peter Weissberg
Identification of the Vulnerable Plaque: The Role of Thermography, Konstantinos Toutouzas, Sophia Vaina, and Christodoulos Stefanadis
Treatment of Vulnerable Plaque: Current and Future Strategies, Leonard Kritharides, David Brieger, S. Benedict Freedman, and Harry C. Lowe
"…provides a thorough review of the pathogenesis and management of atherosclerotic disease and is useful for those diagnosing and managing patients with acute coronary syndromes."
- Christopher J. White, MD, Doody's Book Review Service
"…this book represents a valuable tool for both the novice and the scholar who are interested in this topic and provides an excellent source of reference material."
-New England Journal of Medicine, July 2005
"The final chapter on treatment of vulnerable plaques (current and future) is a real tour de force."
-Scott Kinlay, Harvard Medical School in the Journal of Vascular Medicine