This book presents current recommendations for vaccination for pre- and post-exposure prophylaxis in all suitable target populations and groups. It provides immunization guidelines from the Occupational Safety and Health Administration for health care workers and others at occupational risk of exposure and for routine vaccinations by the Immune Practices Advisory Committee of the Centers for Disease Control.;Covering all aspects of the production, testing and applications of Hepatitis B vaccines, this book: lists all available vaccines worldwide; discusses all serological assays in the field; examines how the vaccine was tested in international clinical trials; describes new programmes for universal immunization of infants; and reveals how the vaccine may prevent some forms of hepatocellular carcinoma.;The book should be of interest to: infectious disease specialists, clinical virologists, immunologists, haematologists, oncologists, hepatologists and gastroenterologists, paediatricians, pharmacologists, molecular biologists, biochemists, biotechnologists, genetic engineers, occupational safety administrators and public health specialists; and upper level undergraduate, graduate and medical school students of these disciplines.
Table of Contents
Recommendations for prevention of hepatitis B with vaccine, Gary B. Calandra and David J. West; plasma-derived hepatitis B vaccine - a breakthrough in preventive medicine, Maurice R. Hilleman; functions of hepatitis B virus proteins and molecular targets for protective immunity, Wolfram H. Gerlich and Volker Bruss; survey of licensed hepatitis B vaccines and their production processes, Robert D. Sitrin et al; quality control of hepatitis B vaccine, Victor P. Grachev and David I. Magrath; serological assays, William J. Miller; epidemiology of hepatitis B virus infection, Stephen C. Hadler and Harold S. Margolis; scope and design of hepatitis B vaccine clinical trials, David J. West; overview of clinical trials in low-endemic areas, Catherine L. Troisi and F. Blaine Hollinger; overview of clinical studies in developing countries, Pierre Coursaget and Mark A. Kane; hepatitis B vaccination - overview of clinical studies in the Far East, E.K. Yeoh and Betty Young; protective efficacy of hepatitis B vaccines in infants, children and adults, Brian J. McMahon and Robert B. Wainwright; prevention of hepatocellular carcinoma, Juei-Low Sung et al; hepatitis B vaccination of children in endemic areas, Alexander Milne and Christopher D. Moyes; prevention of hepatitis B virus infection among health-care workers, Eric E. Mast and Miriam J. Alter; global control of hepatitis B through universal infant immunization, Mark A. Kane; needs unfulfilled by current hepatitis B vaccines, Patricia L. Hibberd et al; variant hepatitis B and D viruses, Tim J. Harrison and Arie J. Zuckerman; application of synthetic peptide technology to experimental hepatitis B vaccine design, David R. Milich; potential future recombinant vaccines, Tineke Rutgers et al.