Hematopoietic Stem Cell Transplantation

1st Edition

Anthony D. Ho, Rainer Haas, Richard E. Champlin

CRC Press
December 20, 2019 Forthcoming
Reference - 624 Pages
ISBN 9780367398316 - CAT# K449335

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Summary

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more.
Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life.
Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation
  • summarizes current understanding and development of clinical allogeneic HSC transplantation
  • discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation
  • considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors
  • details detection of bone marrow contamination by tumor cells and removal procedures
  • focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors
  • explores the effects of growth factor administration and leukapheresis on PB stem cell donors
  • shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use
  • reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells
  • employs automated fluorescence image cytometry to study early HSC behavior following seeding
    Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study,
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