Helicobacter pylori: Biology and Clinical Practice is the first book to fully describe H. pylori and the pathogenesis of H. pylori infections. It delineates the genome of H. pylori, discusses the molecular biology of the unique urease enzyme, and examines the clinical application of these discoveries. The book describes the epidemiology of H. pylori and its relevance to gastric cancer, and it offers clear guidance to clinicians for the diagnosis and treatment of peptic ulcer and non-ulcer dyspepsia in adults and children. Vaccine principles and possibilities are presented for the first time.
Edited by the leader of the microbiology team that achieved the first culture of H. pylori, and named the Helicobacter genus, this book is essential for bacteriologists, gastroenterologists, microbiologists, infectious disease specialists, and other researchers interested in H. pylori.
Table of Contents
1. The Helicobacter Genus- The History of H. pylori and Taxonomy of Current Species S. Goodwin and B. Worsley 2. Ultrastructure of Helicobacter Organisms and Possible Relevance for Pathogenesis A. Lee and J. O'Rourke 3. Histology and Ultrastructure of H. pylori Infections- Gastritis, Duodenitis, and Peptic Ulceration, and Their Relevance as Pre-Cancerous Conditions P. Sipponen, M. Siurala, and S. Goodwin 4. The Worldwide Prevalence of Helicobacter pylori- Asymptomatic Infection, and Clinical States Associated with Infection, in Adults N. Talley and K. Noack 5. Clinical Syndromes of H. pylori Infection in Children S. Gormally, P. Sherman, and B. Drumm 7. Epidemiology of H. pylori Infection and Its Relation to Gastric Cancer H. Mitchell 8. The Metabolism and Enzymes of Helicobacter Pylori- Function and Potential Virulence Effects S. Hazell and G. Mendz 9. Molecular Studies on the Epidemiology and the Pathogenicity of H. pylori Including Plasmids C. Clayton and H. Kleanthous 10. Genome Mapping of Helicobacter Pylori D. Taylor 12. Genetic Organization of the Urease Gene and Its Expression R. Ferrero and A. Labigne 13. Proteins, Antigens, and Typing Methods for Helicobacter Pylori B. Dunn 14. Helicobacter Plori: Receptors and Adhesins C. Lingwood 15. Tissue Culture Models for the Study of H. pylori Pathogenicity F. Megraud and C. Laboisse 16. The Pathogenesis of H. pylori Infection and Duodenal Ulcer- The Gastrin Story and Other Soluble Factors J. Calam 17. Cellular Immunity to Helicobacter Pylori H. Nielsen and L. Andersen 18. Cultural Techniques for the Growth and Isolation of H. Pylori S. Hazell 19. The Antibody Response to H. pylori Infection and the Value of Serological Tests to Detect H. pylori and for Post Treatment Monitoring L. Andersen 20. Breath Tests to Detect Helicobacter pylori R. Logan 21. The Comparative Value of Different Diagnostic Tests for Helicobacter pylori U. Westblom. The Susceptibility of H. pylori to Antibiotics S. Goodwin) Bismuth