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Handbooks in Pharmacology and Toxicology


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PARP as a Therapeutic Target

PARP as a Therapeutic Target

1st Edition

Jei Zhang
March 06, 2002

Recent research in cell death mechanisms has rekindled interest in PARP's (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors' dual...

Molecular Bases of Anesthesia

Molecular Bases of Anesthesia

1st Edition

Eric Moody, Phil Skolnick
December 28, 2000

Molecular Bases of Anesthesia provides a clear overview of the state of knowledge about anesthetic mechanisms at the molecular level of occurrence and focusing on the latest state-of-the-art techniques that relate to how anesthetic drugs cause unconsciousness. With contributions by leading experts,...

Biomedical Applications of Computer Modeling

Biomedical Applications of Computer Modeling

1st Edition

Arthur Christopoulos
September 19, 2000

Up to the last decade or so, most general modeling approaches to the study of molecular components of biological responses have required significant amount of computer time, expertise, and resources, as well as highly specialized and often custom-written programs. With Biomedical Applications of...

Neurotransmitter Receptors in Actions of Antipsychotic Medications

Neurotransmitter Receptors in Actions of Antipsychotic Medications

1st Edition

Michael S. Lidow
June 22, 2000

Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a...

Cell Death: The Role of PARP

Cell Death: The Role of PARP

1st Edition

Csaba Szabo
June 22, 2000

Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in...

Handbook of Alcoholism

Handbook of Alcoholism

1st Edition

Gerald Zernig, Alois Saria, Martin Kurz, Stephanie O'Malley
March 24, 2000

While the war on drugs continues to attract world attention, it is often overlooked that alcoholism remains a major worldwide health concern. No matter what your expertise, the CRC Handbook of Alcoholism can help you acquire the necessary skills to treat problem drinkers and alcohol-dependent...

Manual of Immunological Methods

Manual of Immunological Methods

1st Edition

Canadian Networking
July 02, 1998

The Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be...

Infectious Diseases in Immunocompromised Hosts

Infectious Diseases in Immunocompromised Hosts

1st Edition

Vassil St. Georgiev
December 29, 1997

Because of limited access to medical libraries and medical journals, the majority of clinicians may find it difficult to keep informed on the latest developments in drug manufacture and treatment of infectious diseases in immunocompromised patients. This new handbook strives to fulfill the need for...

Pharmacology of Antimuscarinic Agents

Pharmacology of Antimuscarinic Agents

1st Edition

Laszlo Gyermek
November 25, 1997

The theoretical and practical significance of antimuscarinic drugs is more obvious today than ever before. Antimuscarinics have helped to explore the pathomechanisms of of Alzheimer's disease, and to treat the symptoms of Parkinson's, cardiovascular problems, gastrointestinal diseases, and even...

Anabolic Treatments for Osteoporosis

Anabolic Treatments for Osteoporosis

1st Edition

James F. Whitfield, Paul Morley
October 20, 1997

Osteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at...

Muscarinic Receptor Subtypes in Smooth Muscle

Muscarinic Receptor Subtypes in Smooth Muscle

1st Edition

Richard M. Eglen
January 21, 1997

This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary...

Airway Wall Remodelling in Asthma

Airway Wall Remodelling in Asthma

1st Edition

A. G. Stewart
September 24, 1996

Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma...

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