1024 Pages 7 Color & 340 B/W Illustrations
    by CRC Press

    The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics range from General Toxicology, to Genetic Toxicology, Human Clinical Toxicology, Histopathology, Clinical Pathology, Metabolism and Toxicokinetics, Risk Assessment, and more.

    New to this edition:

    • Completely rewritten chapters covering immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology, providing a fresh perspective on these topics
    • Addition of new chapters on Chemical Toxicology, Pharmaceutical Toxicology, Juvenile Toxicology, and Safety Pharmacology
    • Updated information dealing with Inhalation Toxicology, Neurotoxicology, and Regulatory Toxicology, which has been consolidated into single chapters for each specialty
    • A separate glossary with toxicological terms presented both alphabetically and by toxicological subspecialty

    For nearly 20 years, this handbook has remained the only reference book of its kind, designed to facilitate easy access to information related to the various toxicology specialties. This updated edition of a popular reference book reflects current practices and the state of the science of toxicology.

    Laboratory Animal Management; Joseph C. Siglin, William H. Baker, Aaron M. Sargent, Binod Jacob, and Mark A. Morse

    General Toxicology; Carol S. Auletta

    Dermal Toxicology; Kimberly L. Bonnette

    Ocular Toxicology; Brendan J. Dunn and Kathryn S. Monds

    In Vitro
    Methods for the Prediction of Ocular and Dermal Toxicity; John W. Harbell and Hans Raabe

    Inhalation Toxicology; Gary M. Hoffman, Stuart Cracknell, Justine M. Damiano, Nicholas P. Macri, and Simon Moore

    Neurotoxicology; Rosemary C. Mandella

    Immunotoxicology; Gary R. Burleson, Florence G. Burleson, and Victor J. Johnson

    Renal Toxicology; William J. Powers, Jr.

    Developmental and Reproductive Toxicity; Robert M. Parker

    Juvenile Toxicology; Robert M. Parker

    Endocrine Toxicology; Rochelle W. Tyl

    Genetic Toxicology; Marilyn J. Aardema, Valentine O. Wagner III, Jane J. Clarke, Rohan Kulkarni, Shambhu Roy, Yong Xu, Kamala Pant, Leon F. Stankowski, Jr., Tim Lawlor, and Robert R. Young

    Carcinogenesis; Michael J. Derelanko

    Histopathology; John C. Peckham

    Clinical Pathology; Barry S Levine

    Metabolism and Toxicokinetics of Xenobiotics; Mohamed B. Abou-Donia

    Human Clinical Toxicology; Jill Dolgin and Michael J. Derelanko

    Chemical Toxicology; Michael J. Derelanko

    Pharmaceutical Toxicology; William J. Brock, and Lorrene A. Buckley

    Safety Pharmacology; Theodore J. Baird, Jill A. Dalton, and David V. Gauvin

    Risk Assessment; Michael J. Derelanko

    Regulatory Toxicology; Carol S. Auletta

    Appendix A: LD50 Values
    Appendix B: Tables of Comparative Anatomical, Physiological, and Biochemical Data
    Appendix C: Mathematics, Symbols, Physical Constants, Conversions, and Statistics
    Appendix D: Calculations, Preparation, and Properties of Substances Used in Toxicology
    Appendix E: Design and Performance of Toxicology Studies
    Appendix F: Organizations and Agencies
    Appendix G: Acronyms
    Appendix H: Academic Programs in Toxicology
    Appendix I: Physical/Chemical Information
    Glossary: By Subject
    Index

    Biography

    Michael J. Derelanko, PhD, DABT, FATS, has spent most of his career as a toxicologist in the pharmaceutical and chemical industries. He most recently was director of nonclinical drug safety assessment for Adolor Corporation where he contributed to the discovery and development of novel drugs for nearly ten years. Prior to that, as manager of toxicology and risk assessment for Honeywell International, he supported the company’s chemical businesses for over two decades. He currently is employed by Critical Path Services, a Knoell company, where he provides expertise in toxicology and hazard communication.

    Carol S. Auletta, DABT, RAC, MBA, has worked in toxicology research for more than 30 years. She is board certified in toxicology by the American Board of Toxicology and in regulatory affairs by the Regulatory Affairs Professionals Society. Carol has spent her career in the CRO industry and currently serves as a senior director in safety assessment and the director of program management at Huntingdon Life Sciences in East Millstone, New Jersey.

    "In summary, an excellent book which this review confirms totally adds up to the claim that it is ‘an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia.’ If you are one of these, then buy the book!"
    —Paul Baldrick, Covance Laboratories Ltd, UK in bst News

    "This is an excellent consolidated reference, full of information that is useful to professional toxicologists. There are very few books that serve a similar purpose."
    —Mitchell McGill, PhD, University of Kansas Medical Center in for Doody's Review Service