Several excellent books have been published that address one or more aspects of the diverse field of industrial mycology, but none of them cover the entire process of fungal bioactive metabolites discovery. Until now. The Handbook of Industrial Mycology provides, in one volume, an overview of recent developments in industrial mycology with emphasis on the discovery of bioactive metabolites and, most importantly, their underlying biology and genetics. Two additional features distinguish this book from other books in the field: 1) most chapters are prepared using experimental data to illustrate theories and 2) the authors provide methodologies and experimental protocols in their chapters.
Presenting a comprehensive overview of recent advances, the book provides a framework of basic methods, tools, and organizational principles for channeling fungal germplasm into the academic, pharmaceutical, and enzyme discovery laboratories. It covers the complex range of processes involved in the discovery, characterization, and profiling of bioactive fungal metabolites. The book includes examples of several recently marketed fungal metabolites and explores the impact of fungi on applications in the pharmaceutical, food and beverage, agricultural, and agrochemical industries.
Table of Contents
MYCOLOGY, INDUSTRIAL MYCOLOGY, AND FUNGAL BIOLOGY
Industrial Mycology: Past, Present and Future
Phylogeny of the Fungal Kingdom and Fungal-like Eukaryotes
Biological Activities of Fungal Metabolites
Cell Cycle Regulation in Morphogenesis and Development of Fungi
Agrobacterium-Mediated Transformation of Filamentous Fungi
FUNGAL SECONDARY METABOLITES DISCOVERY
Fungal Germplasm for Drug Discovery and Industrial Applications
Expression of Cosmid-Size DNA of Slow-Growing Fungi in Aspergillus nidulans for Secondary Metabolite Screening
The Isolation and Structure Elucidation of Fungal Metabolites
PCR-Based Data and Secondary Metabolites as Chemotaxonomical Markers in High Throughput Screening for Bioactive Compounds from Fungi
Screening for Biological Activities in Fungal Extracts
Sordarins, Inhibitors of Fungal Elongation Factor 2
BIOSYNTHESIS OF FUNGAL SECONDARY METABOLITES
Secondary Metabolite Gene Clusters
The Aflatoxin Biosynthetic Pathway
Indole-Diterpene Biosynthesis in Ascomycetous Fungi
Loline and Ergot Alkaloids in Grass Endophytes
Biosynthesis of N-methylated peptides in fungi
The Molecular Genetics of Lovastatin and Compactin Biosynthesis
The Aspergillus nidulans Polyketide Synthase WA
FERMENTATION, STRAIN IMPROVEMENT, AND BIOCONVERSION
Pneumocandin B0 Production by Fermentation of the Fungus Glarea lozoyensis: Physiological and Engineering Factors Affecting Titer and Structural-Analogue Formation
Strain Improvement for the Production of Secondary Metabolites
Fungal Bioconversions: Applications to the Manufacture of Pharmaceuticals
Metabolic Engineering Fungal Secondary Metabolic Pathways
HETEROLOGOUS PROTEIN AND ENZYME EXPRESSION IN FUNGI
Heterologous Protein and Enzyme Expression in Fungi
Toxigenic Fungi and Mycotoxin
FUNGI IN BIOLOGICAL CONTROL
Biochemical Basis of Fungi in Biocontrol of Plant Diseases
"This book is a well-organized and superbly researched
publication well suited for researchers engaged in further studying the biochemical basis for the functional effects of tea extracts or components and for healthcare professionals who are inclined to use traditional medicines…"
Journal of Natural Products
"An's book is in the same series of the two edited by Arora and is very much one of a triumvirate, largely complementary rather than duplicatory in content. …Especially well-researched, comprehensive, and authoritative, is the review of 'Biological activities of fungal metabolites' (Peláez). …my recommendation has to be the three superb and largely complementary Marcel Dekker volumes, carefully put together under the keen eye of the series editor, Joan W. Bennett."
-Mycological Research, Oct. 2005
"…the handbook stands alone as a hefty reference guide to industrial exploration of fungi. …International literature is well-represented."
-E-Streams, Vol. 8, No. 9
"The enthusiastic introductory chapter is followed by a wealth of information about the nature, biological activity and taxonomic significance of fungal metabolites… .The book is packed with information and the Editor is to be congratulated on getting together an extensive team of contributors. Although most of the book is concerned with the beneficial use of fungi, one chapter is devoted to a general account of mycotoxins. …this book should surely be on the shelves of any laboratory involved with fungal biotechnology and is an excellent source of information for those involved with teaching and research on fungi."