1st Edition

Handbook of Industrial Mycology

Edited By Zhiqiang An Copyright 2004

    Several excellent books have been published that address one or more aspects of the diverse field of industrial mycology, but none of them cover the entire process of fungal bioactive metabolites discovery. Until now. The Handbook of Industrial Mycology provides, in one volume, an overview of recent developments in industrial mycology with emphasis on the discovery of bioactive metabolites and, most importantly, their underlying biology and genetics. Two additional features distinguish this book from other books in the field: 1) most chapters are prepared using experimental data to illustrate theories and 2) the authors provide methodologies and experimental protocols in their chapters.

    Presenting a comprehensive overview of recent advances, the book provides a framework of basic methods, tools, and organizational principles for channeling fungal germplasm into the academic, pharmaceutical, and enzyme discovery laboratories. It covers the complex range of processes involved in the discovery, characterization, and profiling of bioactive fungal metabolites. The book includes examples of several recently marketed fungal metabolites and explores the impact of fungi on applications in the pharmaceutical, food and beverage, agricultural, and agrochemical industries.

    MYCOLOGY, INDUSTRIAL MYCOLOGY, AND FUNGAL BIOLOGY
    Industrial Mycology: Past, Present and Future
    Phylogeny of the Fungal Kingdom and Fungal-like Eukaryotes
    Biological Activities of Fungal Metabolites
    Cell Cycle Regulation in Morphogenesis and Development of Fungi
    Agrobacterium-Mediated Transformation of Filamentous Fungi

    FUNGAL SECONDARY METABOLITES DISCOVERY
    Fungal Germplasm for Drug Discovery and Industrial Applications
    Expression of Cosmid-Size DNA of Slow-Growing Fungi in Aspergillus nidulans for Secondary Metabolite Screening
    The Isolation and Structure Elucidation of Fungal Metabolites
    PCR-Based Data and Secondary Metabolites as Chemotaxonomical Markers in High Throughput Screening for Bioactive Compounds from Fungi
    Screening for Biological Activities in Fungal Extracts
    Sordarins, Inhibitors of Fungal Elongation Factor 2

    BIOSYNTHESIS OF FUNGAL SECONDARY METABOLITES
    Secondary Metabolite Gene Clusters
    The Aflatoxin Biosynthetic Pathway
    Indole-Diterpene Biosynthesis in Ascomycetous Fungi
    Loline and Ergot Alkaloids in Grass Endophytes
    Biosynthesis of N-methylated peptides in fungi
    The Molecular Genetics of Lovastatin and Compactin Biosynthesis
    The Aspergillus nidulans Polyketide Synthase WA

    FERMENTATION, STRAIN IMPROVEMENT, AND BIOCONVERSION
    Pneumocandin B0 Production by Fermentation of the Fungus Glarea lozoyensis: Physiological and Engineering Factors Affecting Titer and Structural-Analogue Formation
    Strain Improvement for the Production of Secondary Metabolites
    Fungal Bioconversions: Applications to the Manufacture of Pharmaceuticals

    METABOLIC ENGINEERING
    Metabolomics
    Metabolic Engineering Fungal Secondary Metabolic Pathways

    HETEROLOGOUS PROTEIN AND ENZYME EXPRESSION IN FUNGI
    Heterologous Protein and Enzyme Expression in Fungi

    MYCOTOXIN
    Toxigenic Fungi and Mycotoxin

    FUNGI IN BIOLOGICAL CONTROL
    Biochemical Basis of Fungi in Biocontrol of Plant Diseases

    Biography

    Zhiqiang An

    "This book is a well-organized and superbly researched
    publication well suited for researchers engaged in further studying the biochemical basis for the functional effects of tea extracts or components and for healthcare professionals who are inclined to use traditional medicines…"
    Journal of Natural Products

    "An's book is in the same series of the two edited by Arora and is very much one of a triumvirate, largely complementary rather than duplicatory in content. …Especially well-researched, comprehensive, and authoritative, is the review of 'Biological activities of fungal metabolites' (Peláez). …my recommendation has to be the three superb and largely complementary Marcel Dekker volumes, carefully put together under the keen eye of the series editor, Joan W. Bennett."
    -Mycological Research, Oct. 2005

    "…the handbook stands alone as a hefty reference guide to industrial exploration of fungi. …International literature is well-represented."
    -E-Streams, Vol. 8, No. 9

    "The enthusiastic introductory chapter is followed by a wealth of information about the nature, biological activity and taxonomic significance of fungal metabolites… .The book is packed with information and the Editor is to be congratulated on getting together an extensive team of contributors. Although most of the book is concerned with the beneficial use of fungi, one chapter is devoted to a general account of mycotoxins. …this book should surely be on the shelves of any laboratory involved with fungal biotechnology and is an excellent source of information for those involved with teaching and research on fungi."
    -Microbiology Today