1st Edition

Handbook of Clinical Nanomedicine Nanoparticles, Imaging, Therapy, and Clinical Applications

Edited By Raj Bawa, Gerald F. Audette, Israel Rubinstein Copyright 2016
    1708 Pages 211 Color & 73 B/W Illustrations
    by Jenny Stanford Publishing

    This handbook (55 chapters) provides a comprehensive roadmap of basic research in nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine, it not only highlights current advances in diagnostics and therapeutics but also explores related issues like nomenclature, historical developments, regulatory aspects, nanosimilars and 3D nanofabrication. While bridging the gap between basic biomedical research, engineering, medicine and law, the handbook provides a thorough understanding of nano’s potential to address (i) medical problems from both the patient and health provider's perspective, and (ii) current applications and their potential in a healthcare setting.

    GENERAL INTRODUCTION AND BEGINNINGS

    Science at the Nanoscale: Introduction and Historical Perspective
    Chin Wee Shong, PhD, Sow Chorng Haur, PhD, and Andrew T. S. Wee, PhD

    Nanomedicine: Dynamic Integration of Nanotechnology with Biomedical Science
    Ki-Bum Lee, PhD, Aniruddh Solanki, PhD, John Dongun Kim, PhD, and Jongjin Jung, PhD

    A Small Introduction to the World of Nanomedicine
    Rutledge Ellis-Behnke, PhD

    Top Ten Recent Nanomedical Research Advances
    Melanie Swan, MBA

    The Coming Era of Nanomedicine
    Fritz Allhoff, JD, PhD

    What’s in a Name? Defining "Nano" in the Context of Drug Delivery
    Raj Bawa, MS, PhD

    NANOPARTICLES, NANODEVICES, AND IMAGING

    Properties of Nanoparticulate Materials
    Takuya Tsuzuki, PhD

    Solid Drug Nanoparticles: Methods for Production and Pharmacokinetic Benefits
    Andrew Owen, PhD, and Steve P. Rannard, DPhil

    Design and Development of Approved Nanopharmaceutical Products
    Heidi M. Mansour, PhD, RPh, Chun-Woong Park, PhD, and Raj Bawa, MS, PhD

    Nanosizing Approaches in Drug Delivery
    Sandip Chavhan, PhD, Kailash Petkar, PhD, and Krutika Sawant, PhD

    Multilayered Nanoparticles for Personalized Medicine: Translation into Clinical Markets
    Dania Movia, PhD, Craig Poland, PhD, Lang Tran, PhD, Yuri Volkov, PhD, and Adriele Prina-Mello, PhD

    Nanomaterials for Pharmaceutical Applications
    Brigitta Loretz, PhD, Ratnesh Jain, PhD, Prajakta Dandekar, PhD, Carolin Thiele, PhD, Yamada Hiroe, PhD, Babak Mostaghaci, PhD, Lian Qiong, MSc, and Claus-Michael Lehr, PhD

    Polysaccharides as Nanomaterials for Therapeutics
    Shoshy Mizrahy, MSc, and Dan Peer, PhD

    The Story of C60 Buckminsterfullerene
    Harold W. Kroto, PhD

    Applications of Nanoparticles in Medical Imaging
    Jason L. J. Dearling, PhD, and Alan B. Packard, PhD

    Nanoimaging for Nanomedicine
    Yuri L. Lyubchenko, PhD, DSc, Yuliang Zhang, Alexey V. Krasnoslobodtsev, PhD, and Jean-Christophe Rochet, PhD

    Nanoparticles for Multi-Modality Diagnostic Imaging and Drug Delivery
    Catherine M. Lockhart, PharmD, and Rodney J. Y. Ho, PhD

    Magnetic Nanoparticles for Magnetic Resonance Imaging: A Translational Push toward Theranostics
    Ryan A. Ortega, Thomas E. Yankeelov, PhD, and Todd D. Giorgio, PhD

    First-in-Human Molecular Targeting and Cancer Imaging Using Ultrasmall Dual-Modality C Dots
    Michelle S. Bradbury, MD, PhD, and Ulrich Wiesner, PhD

    Atomic Force Microscopy for Nanomedicine
    Shivani Sharma, PhD, and James K. Gimzewski, PhD

    Atomic Force Microscopy Imaging and Probing of Amyloid Nanoaggregates
    Yuri L. Lyubchenko, PhD, DSc, and Luda S. Shlyakhtenko, PhD

    Image-Based High-Content Analysis, Stem Cells and Nanomedicines: A Novel Strategy for Drug Discovery
    Leonardo J. Solmesky, PhD, Yonatan Adalist, MSc, and Miguel Weil, PhD

    Viral Nanoparticles: Tools for Materials Science and Biomedicine
    Nicole F. Steinmetz, PhD, and Marianne Manchester, PhD

    Bacterial Secretion Systems: Nanomachines for Infection and Genetic Diversity
    Agnesa Shala, PhD, Michele Ferraro, MSc, and Gerald F. Audette, PhD

    The Vascular Cartographic Scanning Nanodevice
    Frank J. Boehm

    Advancements in Ophthalmic Glucose Nanosensors for Diabetes Management
    Angelika Domschke, PhD

    THERAPY AND CLINICAL APPLICATIONS

    Towards Nanodiagnostics for Bacterial Infections
    Georgette B. Salieb-Beugelaar, PhD, and Patrick R. Hunziker, MD

    Copaxone® in the Era of Biosimilars and Nanosimilars
    Jill B. Conner, MS, PhD, Raj Bawa, MS, PhD, J. Michael Nicholas, PhD, and Vera Weinstein, PhD

    Doxil®: The First FDA-Approved Nanodrug—From an Idea to a Product (January 2015 Update)
    Yechezkel Barenholz, PhD

    Nanotechnology and the Skin Barrier: Topical and Transdermal Nanocarrier-Based Delivery
    Hagar I. Labouta, PhD, and Marc Schneider, PhD

    Application of Nanotechnology in Non-Invasive Topical Gene Therapy
    Mahmoud Elsabahy, PhD, Maria Jimena Loureiro, MSc, and Marianna Foldvari, PhD, DPharmSci

    Nanocarriers in the Therapy of Inflammatory Disease
    Alf Lamprecht, PhD

    Advanced 3D Nano/Microfabrication Techniques for Tissue and Organ Regeneration
    Benjamin Holmes, MSc, Thomas J. Webster, PhD, and Lijie Grace Zhang, PhD

    Nanomedicine for Acute Lung Injury/Acute Respiratory Distress Syndrome: A Shifting Paradigm?
    Ruxana T. Sadikot, MD, and Israel Rubinstein, MD

    Nanoviricides: Targeted Anti-Viral Nanomaterials
    Randall W. Barton, PhD, Jayant G. Tatake, PhD, and Anil R. Diwan, PhD

    Nanotechnology in Tissue Engineering for Orthopaedics
    Lesley M. Hamming, PhD, JD, and Mark G. Hamming, MD

    Applications of Nanomaterials in Dentistry
    Karolina Jurczyk, DDS, PhD, and Mieczyslaw Jurczyk, PhD, DSc

    Biomimetic Applications in Regenerative Medicine: Scaffolds, Transplantation Modules, Tissue Homing Devices, and Stem Cells
    David W. Green, PhD, and Besim Ben-Nissan, PhD

    Potential Applications of Nanotechnology in the Nutraceutical Sector
    Shu Wang, MD, PhD, and Jia Zhang, MS

    Designing Nanocarriers for the Effective Treatment of Cardiovascular Diseases
    Bhuvaneshwar Vaidya, MPharm, PhD, and Suresh P. Vyas, MPharm, PhD

    Carbon Nanotubes as Substrates for Neuronal Growth
    Cécilia Ménard-Moyon, PhD

    Polymeric Nanoparticles for Cancer Therapeutics
    Mohit S. Verma, Joshua E. Rosen, Ameena Meerasa, Serge Yoffe, MEng, and Frank X. Gu, PhD

    Nanotechnology for Radiation Oncology
    Srinivas Sridhar, PhD, Ross Berbeco, PhD, Robert A. Cormack, PhD, and G. M. Makrigiorgos, PhD

    Gold Nanoparticles against Cancer
    Joan Comenge, PhD, Francisco Romero, PhD, Aurora Conill, MS, and Víctor F. Puntes, PhD

    Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Cancer Therapy
    Melike Üner, PhD

    Nanomedicines Targeted to Aberrant Cancer Signaling and Epigenetics
    Archana Retnakumari, MTech, Parwathy Chandran, MTech, Ranjith Ramachandran, MSc, Giridharan L. Malarvizhi, MTech, Shantikumar Nair, PhD, and Manzoor Koyakutty, PhD

    Biodegradable Nanoparticle-Based Antiretroviral Therapy across the Blood-Brain Barrier
    Supriya D. Mahajan, PhD, Yun Yu, PhD, Ravikumar Aalinkeel, PhD, Jessica L. Reynolds, PhD, Bindukumar B. Nair, PhD, Manoj J. Mammen, MD, Tracey A. Ignatowski, PhD, Chong Cheng, PhD, and Stanley A. Schwartz, PhD, MD

    HIV-Specific Immunotherapy with Synthetic Pathogen-Like Nanoparticles
    Orsolya Lorincz, PhD, and Julianna Lisziewicz, PhD

    Biomedical Engineering and Nanoneurosurgery: From the Laboratory to the Operating Room
    Mario Ganau, MD, PhD, Roberto I. Foroni, PhD, Andrea Soddu, PhD, and Rossano Ambu, MD

    Nanotechnology-Based Systems for Microbicide Development
    Rute Nunes, Carole Sousa, Bruno Sarmento, PhD, and José das Neves, PhD

    Nanotechnology-Based Solutions to Combat the Emerging Threat of Superbugs: Current Scenario and Future Prospects
    Nisha C. Kalarickal, PhD, and Yashwant R. Mahajan, PhD

    Nanolithography and Biochips’ Role in Viral Detection
    Inbal Tsarfati-BarAd and Levi A. Gheber, PhD

    Lectins as Nano-Tools in Drug Delivery
    Anita Gupta, MSc, PhD, and G. S. Gupta, MSc, PhD

    Diagnostics of Ebola Hemorrhagic Fever Virus
    Ariel Sobarzo, PhD, Robert S. Marks, PhD, and Leslie Lobel, MD, PhD

    Nanomedicine as a Strategy to Fight Thrombotic Diseases
    Mariana Varna, PhD, Maya Juenet, MSc, Richard Bayles, PhD, Mikael Mazighi, MD, PhD, Cédric Chauvierre, PhD, and Didier Letourneur, PhD

    Biography

    Raj Bawa, MS, PhD , is president of Bawa Biotech LLC, a biotech/pharma consultancy and patent law firm based in Ashburn, Virginia that he founded in 2002. He is an inventor, entrepreneur, professor and registered patent agent licensed to practice before the US Patent & Trademark Office. Trained as a biochemist and microbiologist, he has been an active researcher for over two decades. He has extensive expertise in the pharmaceutical sciences, biotechnology, nanomedicine, drug delivery, biodefense, FDA regulatory issues, and patent law. Since 1999, he has held various adjunct faculty positions at Rensselaer Polytechnic Institute in Troy, NY, where he is currently an adjunct professor of biological sciences and where he received his doctoral degree in three years (biophysics/biochemistry). Since 2004, he has been an adjunct professor of natural and applied sciences at NVCC in Annandale, VA. He is a scientific advisor to Teva Pharmaceutical Industries, Ltd., Israel. He has served as a principal investigator of National Cancer Institute SBIRs and reviewer for both the National Institutes of Health and the National Science Foundation. In the 1990s, Dr. Bawa held various positions at the US Patent & Trademark Office, including primary examiner for 6 years. He is a life member of Sigma Xi, co-chair of the Nanotech Committee of the American Bar Association and serves on the Global Advisory Council of the World Future Society. He has authored over 100 publications, co-edited four texts and serves on the editorial boards of numerous peer-reviewed journals, including serving as a special associate editor of Nanomedicine (Elsevier) and an editor-in-chief of the Journal of Interdisciplinary Nanomedicine (Wiley). Some of Dr. Bawa's awards include the Innovations Prize from the Institution of Mechanical Engineers, London, UK (2008), the Key Award from Rensselaer's Office of Alumni Relations (2005) and the Lifetime Achievement Award from the

    "Dr. Bawa and his team have meticulously gathered the distilled experience of world-class researchers, clinicians and business leaders addressing the most salient issues confronted in product concept development and translation. Knowledge is power, particularly in nanomedicine translation, and this handbook is an essential guide that illustrates and clarifies our way to commercial success."
    —Gregory Lanza, MD, PhD, Professor of Medicine and Oliver M. Langenberg Distinguished Professor, Washington University Medical School, USA

    "This is an outstanding, comprehensive volume that crosscuts disciplines and topics fitting individuals from a variety of fields looking to become knowledgeable in medical nanotech research and its translation from the bench to the bedside."
    —Shaker A. Mousa, PhD, MBA, Vice Provost and Professor of Pharmacology, Albany College of Pharmacy and Health Sciences, USA

    "Masterful! This handbook will have a welcome place in the hands of students, educators, clinicians and experienced scientists alike. In a rapidly evolving arena, the authors have harnessed the field and its future by highlighting both current and future needs in diagnosis and therapies. Bravo!"
    —Howard E. Gendelman, MD, Margaret R. Larson Professor and Chair, University of Nebraska Medical Center, USA

    "It is refreshing to see a handbook that does not merely focus on preclinical aspects or exaggerated projections of nanomedicine. Unlike other books, this handbook not only highlights current advances in diagnostics and therapies but also addresses critical issues like terminology, regulatory aspects and personalized medicine."
    —Gert Storm, PhD, Professor of Pharmaceutics, Utrecht University, The Netherlands