"Presents state-of-the-art methods for the synthesis, analysis, and conformational investigation of glycoproteins and glycopeptides. Discusses the history of glycopeptide synthesis, therapeutic applications, and the future of research."
Table of Contents
Glycopeptides and glycoproteins - their past, present, and future; recent advances in the synthesis of glycopeptides; enzymatic synthesis of oligosaccharides and glycopeptides; chemical synthesis of glycoprotein glycans; synthesis of oligosaccharides and glycopeptides on insoluble and soluble supports; chemical synthesis of the peptide moiety of glycopeptides; synthesis of glycosylphosphatidylinositol anchors; analysis of GPI protein anchors and related glycolipids; synthesis of intermediates in the dolichol pathway of protein glycosylation; synthesis of inhibitors of the glycosidases and glycosyltransferases involved in the biosynthesis and degradation of glycoproteins; use of permethylation with GC-MS for linkage and sequence analysis of oligosaccharides historical perspectives and recent developments; structural determination of protein-bound oligosaccharides by mass spectrometry; approaches to the structural determination of oligosaccharides and glycopeptides by NMR; conformational studies of glycoprotein glycans using NMR and molecule dynamics; glycopeptides in the immunotherapy of cancer.
"This is a very special book. . . Every school with a graduate program in organic chemistry should have this book in its library. "
---Journal of Medicinal Chemistry
". . .a valuable resource. "
---The European Peptide Society Newsletter
". . .a valuable manual for specialists in the fields of biochemistry, bioorganic chemistry, synthetic chemistry, pharmacology, and interdisciplinary sciences."