The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover, continuous development of novel and selective drugs has revealed detailed information on the mechanism of receptor activation and regulation. However, the rapid development of different aspects of glutamate and GABA receptor research makes it increasingly difficult to establish a general view of the field. Studies of the receptors are a multi-disciplinary task employing many specialised techniques. This book conveys recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field. Universities offering programs in neuroscience, molecular pharmacology or medicinal chemistry will find this a valuable reference.
Table of Contents
1. Ionotropic Glutamate Receptors: Functional and Pharmacological Properties in Relation to Constituent Subunits, Stuart G. Cull-Candy 2. Molecular Structure of Ionotropic Glutamate Receptors, Jan Egebjerg and Henrik S Jensen 3. Glutamate Receptor Trafficking, Guido Meyer and Jeremy M. Henley 4. Pharmacology of NMDA Receptors, David E. Jane 5. Pharmacology of AMPA/kainate Receptors, Ulf Madsen, Tommy N. Johansen, Tine B. Stensbøl and Povl Krogsgaard-Larsen 6. Metabotropic Glutamate Receptors (mGluRs): Structure and Functions, J-P. Pin, L. Fagni and J. Bockaert 7. Pharmacology of Metabotropic Receptors, Darryle D. Schoepp and James A. Monn 8. Insights into GABAA Receptor Complexity From the Study of Cerebellar Granule Cells: Synaptic and Extrasynaptic Receptors, William Wisden and Mark Farrant 9. GABAA Receptor Complex: Structure and Function, Richard W. Olsen and Robert L. Macdonald 10. GABAA Receptor Complex: Structural Requirements for Ligand Interactions, P. Krogsgaard-Larsen, B. Ebert, U. Kristiansen, B. Madsen 11. Molecular Structure of the GABAB Receptors, N. Klix and B. Bettler 12. Phamacology of GABAB Receptors, N. G. Bowery 13. Structure, Function and Regulation of Glutamate Transporters, Line M. Levy 14. GABA Transporters: Functional and Pharmacological Properties, Arne Schousboe and Baruch Kanner 15. Transgenic Models for Glutamate Receptor Function, A.J. Doherty and G.L. Collingridge 16. Transgenic Models for GABAA Receptor Function, H. Möhler 17. Glutamatergic transmission: Therapeutic Prospects for Schizophrenia and Alzheimer's Disease, Nuri B. Farber, John W. Newcomer and John W. Olney 18. GABA-ergic Transmission: Therapeutic Prospects, Christian Thomsen and Bjarke Ebert MRC Centre, UK, R. Dingledine, Emory University of Medicine, USA, D.E. Jane, Univeristy of Bristol, UK, U. Madsen, Danish School of Pharmacy, S. Nakanishi, Kyoto University Faculty of Medicine, Japan, P.L. Ornstien and D.D. Schoepp, Lilly Corporate Centre, USA, M. Neilsen, St Hans Hospital, Denmark, R.L. Macdonald, University of Michegan Medical Centre, USA and R. Olsen, University of California, USA, P. Krogsgaard-Larsen, Danish School of Pharmacy, B. Bettler, Novartis Pharma Inc., Switzerland, W. Froestl, Novartis Pharma Inc., Switzerland, G. Gegelashvili, Danish School of Pharmacy, N.C. Damnbolt, University of Oslo, Norway, A. Shousboe, Danish School of Pharmacy, B.I. Kanner, The Hebrew University, Israel, G.L. Collingridge, Bristol University, UK, E. Möhler, Institute of Pharmacology, Switzerland, J. Drejer, NeuroSearch, Denmark, A.G. Chapman, Institute of Psychiatry, UK.