Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!
This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.
Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!
Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment
reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis
calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens
reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models
discusses the threshold concept of carcinogenesis
demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens
considers structural activity relationship (SAR) analysis of chemical carcinogenicity
describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays
illustrates the use of genetic biomarkers for dosimetry analysis
Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
Table of Contents
Human Cancer Genetics
Jason W. Barlow and David Malkin
Genetic Toxicity Tests for Predicting Carcinogenicity
Genotoxic and Nongenotoxic Mechanisms of Carcinogenesis
Wai Nang Choy
Structure-Activity Relationship (SAR) and its Roles in Cancer Risk Assessment
David Y. Lai and Yin-tak Woo
Regulatory Genetic Toxicology Tests
Wai Nang Choy
Complementary Genetic Toxicology Assays
B. Bhaskar Gollapudi
The Mouse Lymphoma Assay (MLA) Using the Microwell Method
Masamitsu Honma and Toshio Sofuni
The In Vitro Micronucleus Assay
Marilyn J. Aardema and Micheline Kirsch-Volders
ICH Guidelines on Genotoxicity and Carcinogenicity: Scientific Background and Regulatory Practice
Lutz Müller, Peter Kasper, and Leonard Schechtman
New OECD Genetic Toxicology Guidelines and Interpretation of Results
Michael C. Cimino
Dose-Response Relationships in Chemical Carcinogenesis and Cancer Risk Assessment
Werner K. Lutz
Molecular Epidemiology and Biomarkers
Jia-Sheng Wang, Jonathan M. Links, John Groopman
Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens
Anna M. Fan and Robert A. Howd
Risk Assessment of Genotoxic Carcinogens
Biologically Based Cancer Risk Assessment Models
Suresh H. Moolgavkar
…engaging and informative….
…a useful contribution to the field of genetic toxicology.
…a great reference material.
"-Australian Journal of Medical Science
"…offers the reader an authoritative, practical insight.