Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Third Edition

Nancy Smyth Templeton

October 6, 2008 by CRC Press
Reference - 1120 Pages - 325 B/W Illustrations
ISBN 9780849387685 - CAT# 8768

This product is not available
FREE Standard Shipping!


  • Addresses all aspects of gene and cell therapy
  • Includes fundamental basics as well as state-of-the-art advances
  • Features 12 new chapters covering such topics as tissue engineering, human embryonic stem cells, and nanotechnologies
  • Discusses gene therapy from the perspective of many disciplines, including virology, molecular biology, immunology, chemistry, pharmacology, and other sciences


Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression.

New Topics Covered in this Edition:

  • Gene and Cell Therapies for Diabetes and Cardiovascular Diseases
  • Clinical Trials
  • Human Embryonic Stem Cells
  • Tissue Engineering Combined with Cell Therapies
  • Novel Polymers
  • Relevant Nanotechnologies
  • SiRNA Therapeutic Strategies
  • Dendrimer Technologies
  • Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies.

    The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness.

    The final section discusses recent clinical trials and regulatory issues surrounding the new technology.

    This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.