Gene and Cell Delivery for Intervertebral Disc Degeneration

1st Edition

Raquel Madeira Gonçalves, Mario Adolfo Barbosa

CRC Press
Published May 8, 2018
Reference - 259 Pages - 13 Color & 10 B/W Illustrations
ISBN 9781498799409 - CAT# K30583
Series: Gene and Cell Therapy

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Intervertebral disc degeneration is one of the major causes of lower back pain for which the common therapeutic interventions are not efficient. A search for alternative therapies for lower back pain and intervertebral disc degeneration includes cell-based therapies. Unfortunately, intervertebral disc degeneration is avascular and thus a hostile environment for cell survival. Furthermore, cellular characterization in intervertebral disc degeneration, and particularly in the nucleus pulposus, is controversial, mainly due to lack of specific markers and species variability. This book adds to the knowledge on cellular and molecular therapies for intervertebral disc degeneration and associated lower back pain.