Containing a 12-page color insert, this sourceexplores the applications, advantages, and limitations of the major gene therapy vectors including adenovirus, AAV, lentivirus, HSV, and non-viral vector systemsanalyzes the brain immune response to gene therapy vectors using cutting-edge technologiesprovides thorough analyses of human clinical trial results for several vector systems and approachescovers major neurological disorders including Parkinson's disease, Alzheimer's disease, multiple sclerosis, chronic pain, and brain cancer
Coedited by internationally recognized leaders in gene therapy research, this guide supplies the most recent advances, studies, and expert opinion on gene therapy for neurological disorders. Spanning conditions such as Parkinsons's and Alzheimer's disease, multiple sclerosis, brain tumors, stroke, epilepsy, and brain and spinal cord trauma, this reference presents the basic science and applications of recombinant gene products, immune and stem cell-mediated therapeutic strategies, and brain tumor gene therapy.
Table of Contents
Immune Responses to Viral Vectors: Implications for Neurological Gene Therapy. Gene Transfer to the Nerve System Using HSV-1-Derived Amplicon Vectors. Adeno Associated Viral Vectors for the Nervous System. Heat Shock Proteins for Neurological Gene Therapy. iBAC Technologies for Neurological Disease. Targeted Gene Modification of the Nervous System. Astrocytes as Targets for Neurological Gene Therapy. Targeting Non-Viral Gene Transfer Vectors: What We Learn From Viruses & Other Pathogens. Gene Therapy Applications for Parkinson's Disease. HSV-Mediated Gene Transfer in the Treatment of Chronic Pain. Immunotherapeutic Approaches for Alzheimer's Disease. Gene Therapy of Multiple Sclerosis and in CNS Autoimmune Mouse Models. Novel Gene Therapeutic Approaches to Brain Cancer. Vaccines and Beneficial Immunity in Glioma Patients. Replicating Viruses for Brain Tumor Treatment. Adenovirus-mediated HSV-tk Gene Therapy for Malignant Glioma: Clinical Experience