This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms.
Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity!
With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology
focuses on important biological signaling molecules such as superoxide anion and nitric oxide
evaluates the action of low levels of oxygen- and nitrogen-centered radicals on cell membranes and receptors to modulate signal transduction pathways and gene expression
links high mitochondrial density in neural tissue to brain disease
considers how prions and -amyloid proteins influence the level of free radicals within cells
assesses the abnormalities of superoxide dismutase in the familial form of amyotrophic lateral sclerosis
highlights the occurrence of oxidative stress and the impact of oxidative injury in brain physiology and neurodegeneration
With contributions from nearly 70 internationally recognized researchers, physiologists, and clinicians who describe their latest findings and provide new insights into the factors underlying neurological disorders, Free Radicals in Brain Pathophysiology is an unsurpassed reference for nutritionists and dietitians, clinical neurologists, pathologists, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.
Table of Contents
Free Radicals and Antioxidants in Brain Pathophysiology
The Role of Free Radicals in the Brain in Health and Disease in Relation to Synaptic Plasticity
Neuromodulatory Effects of Nitric Oxide in Pain Perception
Adalberto Merighi, Patrizia Aimar, Laura Lossi, Lucia Pasti, and Giorgio Carmignoto
Ischemic and Metabolic Stress-Induced Apoptosis
James David Adams, Jr., Lawrence R. Williams, Suman K. Mukherjee, Lori Klaidman, Glen Inouye, Vierka Cummins, and Maria Morales
Nitrogen Radicals in Ischemic Damage of the Brain
Neuroinflammatory Events and Enhanced Signal Transduction Processes Involved in Neurodegeneration
Robert A. Floyd, C. A. Stewart, K. A. Robinson, G. Bing, and K. Hensley
Free Radicals in Glutaate and Catecholamine-Mediated Neurotoxicity
Oxidative Stress in Glutamate Neurotoxicity
Derick S. Han, Enrique Cadenas, Michael S. Kobayashi, and Lester Packer
Modulation of Glutamate Release and Toxicity by Nitric Oxide
C. M. Carvalho, S. M. Sequeira, C. B. Duarte, and Ansélio P. Carvalho
Interplay Between Oxidative Stress and Calcium Homeostasis in Acute Neuronal Damage and Neurodegenerative Disease
Julie K. Andersen and Veena Viswanath
MAO Knockout Mice and Behavior
Jean Chen Shih, K. Chen, and M. J. Ridd
DNA Strand Breakage Induced by Nitric Oxide Together with Catecholamine: Implications for Neurodegenerative Diseases
Hiroshi Ohshima, Yumiko Yoshie, and Isabelle Gilibert
6-Hydroxydopamine, Dopamine, and Ferritin: A Cycle of Reactions Sustaining Parkinson's Disease?
G. N. L. Jameson and Wolfgang Linert
Free Radicals and Antioxidants in Neurological Disorders
ROS and Parkinson's Disease: A View to a Kill
Serge Przedborski and Vernice R. Jackson-Lewis
Nitric Oxide Overproduction and Oxidative Stress in Human Idiopathic Parkinson's Disease
Emilia Mabel Gatto, Natalia Andrea Riobó, Maria Cecilia Carreras, and Juan José Poderoso
"…up-to-date and comprehensive….an excellent reference for clinicians and scientists in the field of neuroscience.
"-Saudi Medical Journal