Frank Rosenzweig, Gavin Sherlock
September 15, 2018 Forthcoming
Textbook - 400 Pages - 24 Color & 76 B/W Illustrations
ISBN 9781498743181 - CAT# K26828
Experiments using microbes are the best way to make sense of evolution in real time. This edited book highlights the experimental approach, using Viruses, Bacteria, “lower” Eukaryotes and digital organisms. The contributors illustrate the ways this approach is revolutionizing our understanding of adaptation, recombination and mutation rates, speciation and the evolutionary transitions from prokaryotic to eukaryotic and from unicellular to multicellular life forms.
Experimental Microbial Evolution: A Window into the Adaptive Process. Mapping the Adaptive Landscape in a Single Dimension I: Metabolic and Genetic Limits to Optimality. Mapping the Adaptive Landscape in Multiple Dimensions II: Trade-offs, Constraints and Antagonistic Pleiotropy. Genome Evolution I: Evolution of Operons, Regulons and Chromosome Organization. Genome Evolution II: Evolution of Gene and Chromosome Copy Number. Evolution of Genetic Systems I: Mutational Spectra and Mutation Rate. Evolution of Genetic Systems II: Epistasis and Regulatory networks. Experimental Microbial Evolution: Multilevel Selection and Major Transitions. Synergistic interactions I: Genes and Genomes in the Evolution of Cooperation. Synergistic interactions II: Evolution of Organelles and Multicellularity. Synergistic interactions III: Mutualism and Social Evolution. Antagonistic interactions: Host/pathogen Coevolution and the Advent of Temperance, Virulence and Multidrug Resistance. Experimental Microbial Evolution: Evolutionary Engineering in Industry and Biomedicine. Industrial applications I: Evolution of Novel Metabolic Capabilities and Physiological Tolerances. Industrial applications II: Discovering Novel Antimicrobials and Cancer Therapies. Microbial Evolution: The Interplay of Theory and Experiment. Interplay of Theory and Experiment I: Illuminations from in Silico Modeling of Digital Organisms. Interplay of Theory and Experiment II: Connecting Genotype to Phenotype using Systems Biology.