This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.
Table of Contents
"Eosinophil Granule Proteins: Structure and Function, Gerald J. Gleich, Dohn G. Glitz, and Randa I. Abu-Ghazaleh Human Eosinophil Lysophospholipase (Charcot-Leyden Crystal Protein): Molecular Cloning, Expression, and Potential Functions in Asthma, Steven J. Ackerman, Mike A. Clark, Zeqi Zhou, Charles G. Irvin, Daniel G. Tenen, and Yuan-Po Tu G-Protein Regulation of Eosinophil Exocytosis, Oliver Cromwell, Bastien D. Gomperts, and Manfred Lindau Regulation of Eosinophil Function by P-Selectin, Mathew A. Vadas, C. M. Lucas, J. R. Gambel, Angel F. Lopez, M. P. Skinner, and M. C. Berndt Structural Basis for the GM-CSF- and IL-3-Mediated Stimulation of Eosinophil Production and Function in Humans, Angel F. Lopez, J. Woodcock, T. Hercus, S. Barry, P. Dyson, P. Simmons, M. F. Shannon, and Mathew A. Vadas The Role of Adhesion Molecules and Cytokines in Eosinophil Recruitment, Robert P. Schleimer, Motohiro Ebisawa, Steve N. Georas, and Bruce S. Bochner The Role of Adhesion in Eosinophil Accumulation and Activation in Asthma, Andrew J. Wardlaw, Garry M. Walsh, A. R. E. Anwar, Adele Hartnell, Andrew M. Bentley, and A. Barry Kay Eosinophil-Active Cytokines in Human Disease: Development and Use of Monoclonal Antibodies to IL-3, IL-5, and GM-CSF, John S. Abrams, Gerald J. Gleich, Robert E. Van Dyke, and Jon E. Silver Ultrastructural Studies on Mechanisms of Human Eosinophil Activation and Secretion, Ann M. Dvorak Eosinophil Differentiation and Cytokine Networks in Allergic Inflammation, Judah A. Denburg, Jerry Dolovich, Jean Marshall, Isabelle Pin, Peter Gibson, Isao Ohno, Susetta Finotto, Fred Hargreave, and Manel Jordana Eosinophil Membrane Receptors: Function of IgE- and IgA-Binding Molecules, Monique Capron, Marie-JosE Truong, Pierre Desreumaux, BouchaIb Lamkhioued, Margherita Tomassini, and AndrE Capron Cytokine Regulation of Eosinophil-Mediated Inflammatory Reactions by Modulation of Eosinophil Programmed Cell Death and Subsequent Priming for Augmented Function, William F. Owen, Jr. and K. Frank Austen Mast Cell and Eosinophil Cytokines in Allergy and Inflammation, Stephen J. Galli, John R. Gordon, Barry K. Wershil, John J. Costa, Aram Elovic, David T. W. Wong, and Peter F. Weller Eosinophils in Immunological Reactions, Peter F. Weller Eosinophils and Platelet-Activating Factor, Michela Blom, Anton T. J. Tool, Leo Koenderman, Arthur J. Verhoeven, and Dirk Roos Pharmacological Control of Eosinophil Activation and Secretion, Peter J. Barnes and Mark A. Giembycz Transgenic Experiments with Interleukin-5, Colin J. Sanderson, Malcolm Strath, Ian Mudway, and Lindsay A. Dent Interleukin-5 Receptor, Satoshi Takaki, Yoshiyuki Murata, Akira Tominaga, and Kiyoshi Takatsu The Control of Differentiation and Function of the Th2 Subset of CD4+ T Cells, Robert L. Coffman Eosinophils in a Guinea Pig Model of Allergic Airways Disease, M. G. Campos, M-C. Seminario, J. K. Shute, T. C. Hunt, S. T. Holgate, and M. K. Church Asthma, Eosinophils and Interleukin-5, A. Barry Kay, Qutayba Hamid, Douglas S. Robinson, Andrew M. Bentley, Anne Tsicopoulos, Sun Ying, Redwan Moqbel, Christopher J. Corrigan, and Stephen R. Durham Eosinophils and Late-Phase Reactions in Primates, Robert H. Gundel, Craig D. Wegner, and L. Gordon Letts Eosinophils and New Antihistamines, Christine De Vos Eosinophils and Asthma, Julie B. Sedgwick, William F. Calhoun, and William W. Busse Eosinophil Granule Proteins in Cutaneous Disease, Kristin M. Leiferman Summing Up: Eosinophils 1992, Christopher J. F. Spry, Ming-Shi Li, Li Sun, and Takahiro Satoh "