This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues.
Endocrine Therapy in Breast Cancer
details modern techniques for molecular profiling, monitoring, and targeting
offers methods to identify high-risk groups
evaluates molecular biomarkers in breast cancer assessment
examines the potential toxicity of estrogen receptor (ER)-directed endocrine therapy
investigates the development of endocrine resistance
discusses neoadjuvant and preoperative approaches in patient care
reviews mechanisms that lead to estrogen-independent phenotypes
Surveying the medical, surgical, and pathological aspects of endocrine therapy, as well as future research opportunities, Endocrine Therapy in Breast Cancer is a concise and in-depth manual for medical, surgical, and radiation oncologists; endocrinologists; gynecologists; obstetricians; pharmacologists; family physicians; reproductive biologists; epidemiologists; and medical school students.
Table of Contents
Why Endocrine Therapy?
Daniel F. Hayes
Advanced Breast Cancer
Tamoxifen and Advanced Breast Cancer: An Overview
John F. Forbes
Overview of Aromatase Inhibitors and Inactivators in the Treatment of Advanced Breast Cancer
Per Eystein Lønning
Endocrine Treatment of Advanced Breast Cancer-Selective Estrogen-Receptor Modulators (SERMs)
Stephen R. D. Johnston and Anthony Howell
Other Endocrine and Biological Agents in the Treatment of Advanced Breast Cancer