Demonstrates how substitution of a variety of ligands can render albumin a versatile targeting tool for selective drug accumulation in various cell populations of the liver!
This book discusses physical, chemical, and biological approaches to drug targeting technology, focusing on oral, dispersed system, topical, dermal, transdermal, and inhalation delivery, and the development of original formulations that are matched by innovative device design.
Considers the efforts in biotechnology and molecular biology to produce intelligent drug delivery devices by exploiting biological pathways!
Containing over 1100 references to facilitate further study, Drug Targeting Technology
updates recent progress in oral and colonic targeting technology using pH- and enzyme-sensitive coating materials and novel polymer systems
shows how the systemic distribution of drugs can be modulated by lipid-based carriers taking alternative routes of transport, particularly lymph flow
details soft drugs that are rapidly metabolized to inactive and nontoxic metabolites and removed efficiently from the body
includes successful designs of virus-like liposomal delivery systems that offer the advantages of viral carriers
supplies examples of how viral delivery systems can be directed to cancer sites
Suggesting harnessing biological processes as the ultimate approach to the delivery or expression of pharmacologically active agents, Drug Targeting Technology is a top-shelf reference for pharmacists, pharmacologists, and pharmaceutical scientists; analytical, surface, physical, and colloid chemists and biochemists; and upper-level undergraduate and graduate students in these disciplines.
Table of Contents
Physical Targeting Approaches
Enteric Targeting Through Enteric Coating
Bianca Brögmann and Thomas E. Beckert
New Experimental Coating Material for Colon-Specific Drug Delivery
Kurt H. Bauer
Pharmacokinetic Considerations in the Design of Pulmonary Drug Delivery Systems for Glucocorticoids
Cary Mobley and Günther Hochhaus
Lipid-Based Formulations for Oral Administration: Opportunities for Bioavailability Enhancement and Lipoprotein Targeting of Lipophilic Drugs
Christopher J. H. Porter and William N. Charman
Topical Application of Drugs: Mechanisms Involved in Chemical Enhancement
Joke A. Bouwstra, B. A. I. van den Bergh, and M. Suhonen
Chemical Targeting Approaches
Drug Targeting by Retrometabolic Design: Soft Drugs and Chemical Delivery Systems
Nicholas Bodor and Peter Buchwald
Neoglyco- and Neopeptide Albumins for Cell-Specific Delivery of Drugs to Chronically Diseased Livers
Leonie Beljaars, Barbro N. Melgert, Dirk K. F. Meijer, Grietje Molema, and Klaas Poelstra
Biological Targeting Approaches
Gene Delivery with Artificial Viral Envelopes
Frank L. Sorgi, Lucie Gagné, and Hans Schreier
Evolution of Viral Liposomes: Improvements and Applications
Yasufumi Kaneda, Yoshinaga Saeki, and Ryuichi Morishita
Targeting of Viral Vectors for Cancer Gene Therapy
Dirk M. Nettelbeck and Rolf Müller
…gives the reader the possibility of being much informed.
"-IASI Polytechnic Magazine