Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development

1st Edition

Jae Lee, R. Scott Obach, Michael B. Fisher

CRC Press
Published September 3, 2003
Reference - 608 Pages
ISBN 9780824742935 - CAT# DK2865


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Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes - as well as parallel issues shaping the pharmaceutical industry - to promote the next generation of safer, more effective drugs.