Drug-Drug Interactions

2nd Edition

A. David Rodrigues

CRC Press
Published February 8, 2008
Reference - 768 Pages - 106 B/W Illustrations
ISBN 9780849375934 - CAT# DK7593
Series: Drugs and the Pharmaceutical Sciences

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Summary

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:

  • key interplay between transporters and enzymes in drug metabolism and drug interactions
  • the integral role of pharmacogenetics in metabolism-based drug-drug interactions
  • in vivo – in vitro correlations (reversible, mechanism-based inhibition, induction)
  • in silico approaches enabling structure-activity and structure-function studies
  • high-throughput screening and GLP methods for evaluating drug interactions in vitro
  • the use of transgenic animal models to evaluate drug interactions

Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

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