3rd Edition

Drug Delivery Systems

By Vasant V. Ranade, John Cannon Copyright 2011
    608 Pages 114 B/W Illustrations
    by CRC Press

    Drug delivery technologies represent a vast, vital area of research and development in pharmaceuticals. The demand for innovative drug delivery systems continues to grow, driving a variety of new developments. Drug Delivery Systems, Third Edition provides a comprehensive review of the latest research and development on drug delivery systems.

    Coverage includes liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery. Each chapter provides a table of marketed and investigational products with numerous practical examples. The book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives. This third edition contains a chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies.

    Written in a straightforward manner, the authors provide a global perspective on current and future advances and market opportunities. Supplying a cogent overview of the field and extensive guidance on where to get more information, it is an essential resource for anyone venturing into this area of drug development.

    Site-Specific Drug Delivery Using Liposomes and Emulsions as Carriers
    Introduction
    Liposomes in Drug Delivery
    The Liposome-Drug Concept
    Liposomes as Carriers of Therapeutic Agents
    Parenteral Emulsions
    Recent Advances and Future Prospects
    Concluding Remarks
    References

    Site-Specific Drug Delivery Utilizing Monoclonal Antibodies
    Introduction
    Production of Monoclonal Antibodies
    Drug–Monoclonal Antibody Conjugates for Drug Targeting
    Recent Studies with Monoclonal Antibodies
    Conclusion and Basis for Future Trends
    References

    Role of Polymers in Drug Delivery
    Introduction
    Currently Available Polymers
    Soluble Polymers as Drug Carriers
    Biodegradable or Bioerodible Polymers
    Mucoadhesive Polymers
    Polymers Containing Pendant Bioactive Substituents
    Matrix Systems
    Heparin-Releasing Polymers
    Ionic Polymers
    Oligomers
    Miscellaneous
    Recent Advances
    Conclusion
    References

    Implants in Drug Delivery
    Introduction
    Insulin Delivery as a Model Implant Pump System
    Implants for Contraception
    Delivery of Chemotherapeutic Agents Using Implants
    Recent Advances in Implants and Related Devices (Excluding Inserts)
    Future Prospects
    References

    Oral Drug Delivery
    Controlled-Release Formulations
    Introduction
    Features of the GI Tract
    Targeting of Drugs in the GI Tract
    Mathematical Models for Controlled-Release Kinetics
    Design and Fabrication of Oral Delivery Systems
    Survey of Oral Controlled-Release Products
    Recent Advances
    Current Development of Oral Drug Delivery Systems
    Conclusion
    References

    Enhancing Oral Bioavailability
    Introduction
    Increasing Bioavailability of Water-Insoluble Drugs
    Increasing Bioavailability of Proteins, Peptides, and Other Drugs with Absorption Problems
    Recent Advances and Future Prospects
    References

    Transdermal Drug Delivery
    Introduction
    Theoretical Aspects of Transdermal Drug Delivery
    Development of the Transdermal Therapeutic System
    Examples of Transdermal Applications
    Recent Advances and Future Prospects
    Conclusion
    References

    Transmucosal and Ocular Drug Delivery
    Introduction: Transmucosal and Ocular Drug Delivery
    Pulmonary Drug Delivery
    Intranasal Drug Delivery
    Buccal and Sublingual Drug Delivery
    Rectal, Vaginal, and Other Forms of Transmucosal Drug Delivery
    Ocular Drug Delivery
    Conclusions and Future Outlook for Transmucosal
    and Ocular Drug Delivery
    References

    Miscellaneous Forms of Drug Delivery
    Introduction
    Pro-Drugs
    Infusion Devices
    Insulin Delivery
    Recent Advances
    Summary
    References

    Nanoscience and Nanotechnology for Drug Delivery
    Introduction
    Nanotechnologies
    Miscellaneous Applications of Nanomaterials
    Nanoparticles and Nanostructures
    Nanomedicine and Nanopharmaceuticals
    References

    Regulatory Considerations for Drug Delivery Systems
    Introduction
    Current Status of Drug Delivery Technology
    Submission of Documents for Manufacture and Quality
    References

    Drug Delivery Industry and the Global Outlook
    Basis for the Recent Trend
    References

    Biography

    Vasant V. Ranade is the director of chemical sciences for Academic Pharmaceuticals Inc., in Lake Bluff, Illinois.

    John B. Cannon heads his own pharmaceutics and drug delivery consulting company, Targeted Drug Solutions, in Grayslake, Illinois, and serves as a visiting assistant professor at Trinity International University.