Direct and Allosteric Control of Glutamate Receptors describes in detail recent research that has demonstrated that glutamate receptors are subject to numerous modulatory controls. Significant new insights into the physiology and pathophysiology of the nervous system have been obtained by these discoveries. The sites on the receptor proteins where modulation occurs have provided a platform of opportunities for medicinal chemists to design new therapeutic modalities. These new drugs will be of major significance in treating diseases (such as stroke, Alzheimer's, epilepsy, Parkinson's, Huntington's, neurotrauma, schizophrenia, pain, and anxiety) associated with abnormal excitatory amino acid neurotransmission and function.
Table of Contents
Glutamate Receptors and Their Regulators-An Overview (M.G. Palfreyman). The Molecular Pharmacology of Mammalian AMPA and Kainate Receptors (T.A. Verdoorn). Calcium, Magnesium, and Glutamate Receptors (I.J. Reynolds and S. Rajdev). Desensitization and the Short-Term Modulation of AMPA/Kainate Receptors in Vertebrate Neurons (C.F. Zorumski and S.J. Mennerick). Regulation of Glutamate Receptors by Reversible Phosphorylation (J.F. MacDonald, M.C. Bartlett, B.A. Orser, E.J. Fletcher, M.D. Browning, and L.-Y. Wang). Redox Modulation of the NMDA Receptor (E. Aizenman). Design and Pharmacological Evaluation of Highly Selective Glycine Antagonists (B.M. Baron, J.H. Kehne, S.M. Sorensen, B.L. Harrison, F.G. Saliture, and H.S. White). In Vitro and In Vivo Studies with Glycine Partial Agonists: A Novel Strategy for Preventing NMDA Receptor-Medicated Tissue Damage (K.M. Boje). Neuroprotection in NMDA and Non-NMDA Glutamate Antagonists (B.S. Meldrum). Neuroprotective Potential of the Polyamine Site-Directed NMDA Receptor Antagonists Ifenprodil and Eliprodil (B. Scatton, P. Avenet, J. Benavides, C. Carter, D. Duverger, A. Oblin, G. Perrault, D.J. Sanger, and H. Schoemaker). Conantokin-G and Its Analogs: Novel Probes of the NMDA Receptor Associated Polyamine Site (P. Skolnick, L.-M. Zhou, P. Chandler, N.T. Nashed, M. Pennington, and M.-L. Maccecchini).