Direct and Allosteric Control of Glutamate Receptors

1st Edition

Michael G. Palfreyman, Ian J. Reynolds, Phil Skolnick

CRC Press
Published August 16, 1994
Reference - 192 Pages
ISBN 9780849383076 - CAT# 8307
Series: Handbooks in Pharmacology and Toxicology

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Summary

Direct and Allosteric Control of Glutamate Receptors describes in detail recent research that has demonstrated that glutamate receptors are subject to numerous modulatory controls. Significant new insights into the physiology and pathophysiology of the nervous system have been obtained by these discoveries. The sites on the receptor proteins where modulation occurs have provided a platform of opportunities for medicinal chemists to design new therapeutic modalities. These new drugs will be of major significance in treating diseases (such as stroke, Alzheimer's, epilepsy, Parkinson's, Huntington's, neurotrauma, schizophrenia, pain, and anxiety) associated with abnormal excitatory amino acid neurotransmission and function.

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