Despite rapidly increasing interest in developmental immunotoxicology, there is not yet a textbook focused on this hot area of research. Developmental Immunotoxicology fills the void with overviews of immune system development in experimental animal and human models, and discusses the complex issues related to the evolution of developmental immunology and risk assessment.
This text describes different models used to study developmental immunotoxicology and examples of specific developmental immunotoxic agents, including therapeutics. The text concludes with several chapters that describe the role of neuroimmune interactions as they relate to developmental immunotoxicology.
Using a didactic approach, Developmental Immunotoxicology provides an explanatory overview of this cutting-edge field for toxicologists, immunologists, and developmental biologists. It provides a lucid account of this area of research-proposing answers to some questions and stimulating debate on those questions yet to be addressed by the research community.
Table of Contents
DEVELOPMENT OF THE IMMUNE SYSTEM
Development of the Rodent Immune System; K.S. Landreth and S.V.M. Dodson
Development of the Human Immune System; R. Leibnitz
DEVELOPMENTAL IMMUNOTOXICOLOGY: MODELS
Risk Assessment Perspectives for Developmental Immunotoxicology; C.A. Kimmel, M.D. King, and S.L. Makris
The Mouse as a Model for Developmental Immunotoxicology; M.R. Prater, B.L. Blaylock, and S.D. Holladay
The Rat as a Model for Developmental Immunotoxicology; R.J. Smialowicz
The Pig as a Model for Developmental Immunotoxicology; H.J. Röthkotter, E. Sowa, and R. Pabst
The Non-Human Primate as a Model for Developmental Immunotoxicology; A.G. Hendrickx, P. Peterson, and N. Makori
DEVELOPMENTAL IMMUNOTOXICANT EXPOSURE AND POSTNATAL IMMUNOSUPRESSION
Developmental Immunotoxicology of Halogenated Aromatic Hydrocarbons and Polycyclic Aromatic Hydrocarbons; T.C. Hrubee, B.L. Blaylock, and S.D. Holladay
Developmental Immunotoxicity of Chlordane; J.B. Barnett, L.F. Gibson, and K.S. Landreth
Toxicity of Lead to the Developing Immune System; R.R. Dietert and J.-E. Lee
Developmental Immunotoxicity of Therapeutic Immunosuppressive Drugs; R.M. Gogal, Jr. and S.D. Holladay
Mycotoxins and Other Miscellaneous Developmental Immunotoxicants; T.C. Hrubec and S.D. Holladay
DEVELOPMENTAL IMMUNOTOXICANT EXPOSURE AND EXACERBATED POSTNATAL IMMUNE RESPONSES
Prenatal Immunotoxicant Exposure and Autoimmune Disease; B.L. Blaylock, S.A. Ahmed, and S.D. Holladay
Developmental Immunotoxicant Exposure and Exacerbated Postnatal Immune Responses: Asthma; J.M. Armstrong, R.R. Leibnitz, and D. Loer-Martin
Developmental Neurotoxicity and Postnatal Immune Deficits; P.V. Basta
Neuroendocrine-Immune Interactions: Impact of Gender, Negative Energetic Balance Condition, and Developmental Stage on the Mechanisms of the Acute Phase Response of the Inflammatory Process in Mammals, E. Spinedi, N.B. Pérez, and R.C. Gaillard
"This book is the first to consider developmental immunotoxicology … an extremely important contribution to the toxicology literature. … [It] is also timely and provides a treatment of a major current scientific and regulatory issue … a text of high educational and reference value to toxicologists at all levels and across numerous disciplines. … [It] will undoubtedly be influential, as both science and regulatory risk assessment uncover the scale of a potential major human health problem."
- Journal of Applied Toxicology