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Reflecting the embryonic state of the field, the first edition of Dermatoxicology, published in 1977, numbered 567 pages. Now the foundational reference in dermal toxicology, this seventh edition consists of 1,032 pages and defines what was once a largely intuitive field but has evolved into an established science of metrics and mechanisms. Updated
Table of Contents
CONCEPTS. Safety Terminology. Pharmacogenetics and Dermatology. Racial (Ethnic) Differences in Skin Properties: the Objective Data. Occlusion and Barrier Function. Anatomical Factors Affecting Barrier Function. Principles and Practices of Percutaneous Absorption. Calculations of Body Exposure from Percutaneous Absorption Data. Percutaneous Absorption of Complex Chemical Mixtures. Percutaneous Absorption: Short-Term Exposure, Lag Time, Multiple Exposure, Model Variations, and Absorption from Clothing. Lipids of the Permeability Barrier. Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying Interaction of Chemical and Human Skin. Sensitive Skin. Transdermal Drug Delivery System. Iontophoresis. In Vivo Irritation. Irritant Dermatitis (Irritation). Irritant Contact Dermatitis: Is there an Immunologic Component? Systemic Contact Dermatitis. Occupational Issues of Irritant Contact Dermatitis. Allergic Contact Dermatitis. Irritant Contact Dermatitis Versus Allergic Contact Dermatitis. Operational Definition of Occupational Allergic Contact Dermatitis. Systemic Toxicity. Molecular Pathways in Dermatotoxicology. Molecular Basis of Allergic Contact Dermatitis. Photoirritation (Phototoxicity, Phototoxic Dermatitis). Permeability of Human Skin to Metals and Paths for their Diffusion. Chemically Induced Scleroderma. Chemical Agents that Cause Depigmentation. Carcinogenesis: Current Trends in Skin Cancer Research. Retinoids and their Mechanisms of Toxicity. Mechanisms in Cutaneous Drug Hypersensitivity Reactions. Drug Induced Ocular Phototoxicity. Water: Is it an Irritant? Sodium Lauryl Sulfate in Dermatotoxicology. Factors Influencing the Amount of Topical Preparations Applied. Barrier Creams. Organisation for Economic Co-operation and Development (OECD) Guidelines. METHODS. Methods for In Vitro Percutaneous Absorption. Percutaneous Absorption of Hazardous Substances from Soil and Water. Pesticide Percutaneous Absorption and Decontaminat
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CHOICE – Outstanding Academic Title – Award Winner
CHOICE – 2018 Outstanding Academic Title – Award Winner
Shingo Research and Professional Publication Award Winner
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