Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.
Table of Contents
Comparative Anatomy, Physiology, and Biochemistry of Mammalian Skin. Pathological Processes of Skin Damage Related to Toxicant Exposure. Considerations in the Design and Conduct of Subchronic and Chronic Dermal Exposure Studies With Chemicals. Evaluation of the Dermal Irritancy of Chemicals. Dermal Hypersensitivity: Immunologic Principals and Current Methods of Assessment. Cutaneous Photosensitization. Principles of Skin Permeability Relevant to Chemical Exposure. In Vivo Measurement of Dermal Absorption. In Vitro Assessment of Dermal Absorption. Isolated Perfused Skin Flap and Skin Grafting Techniques. In Vitro Alternative Methods for the Assessment of Dermatotoxicity. Use of Dermatotoxicologic Test Data in Product Development and in the Assessment of Chemical Hazards. Statistical Considerations for Ocular and Dermal Toxicology Studies. Comparative Anatomy and Physiology of the Mammalian Eye. Pathological Processes of the Eye Related to Chemical Exposure. Ocular Irritation Testing. Principles and Methods of Ocular Pharmacokinetic Evaluation. Alternative Methods for Assessing the Effects of Chemicals on the Eye. Preclinical Toxicity/Safety Considerations in the Development of Ophthalmic Drugs and Devices. c. 608 pp., 6x9, due June 1991, ISBN 0-8493-8811-2.