DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuroprotective effects of DHEA are presented, as well as insight related to DHEA metabolism in the brain.
A number of health benefits have been associated with dehydroepiandrosterone (DHEA), including anti-cancer, anti-osteoporosis, anti-atherosclerosis, anti-diabetes, immuno-stimulating, and memory-enhancing effects. This has prompted millions of people to take this hormone as a daily nutritional supplement. However, there is some concern that prolonged self-administration may result in future health problems, as well as unease about potential side effects due to the production of steroid derivatives in the tissues.
Featuring an esteemed panel of contributors, this volume provides an authoritative overview of the research concerning DHEA and the brain. It presents a variety of innovative approaches and ideas for future investigations into the physiological actions of this hormone.
Table of Contents
The Brain, a Putative Source and Target of DHEA, Maria Luisa Barbaccia and Tatiana Sidiropoulou
DHEA Metabolites during the Life Span, Richard Hampl, Martin Hill, and Luboslav Stárka
Postulated Roles of DHEA in the Decline of Neural Function with Age, L.-Y. Ngai and J. Herbert
DHEA: Hormone of Youth and Resilience - Still a Maverick, Maria Dorota Majewska
DHEA Effects on Liver, Doris Mayer
DHEA and Brain Development, Synthia H. Mellon
DHEA Metabolism in the Brain: Production and Effects of the 7 -hydroxylated Derivative, M. Trincal, J. Loeper, D.Pompon, J.J. Hauw, and R. Morfin
DHEA: Biosynthesis, Regulation and Function in the Central Nervous System, Rachel C. Brown, Ying Liu, and Vassilios Papadopoulos
Cross-talk Between DHEA and Neuropeptides, Chandan Prasad
DHEA Effects on Human Behaviour and Psychiatric Illness, Victor I. Reis and Owen M. Wolkowitz
Effects of DHEA on Diabetes Mellitus, Kazutaka Aoki and Hisahiko Sekihara
The Clinician's View of DHEA: An Overview, Frank Svec
DHEA Replacement and Cognition in Healthy Elderly Humans, Oliver T. Wolf and Clemens Kirschbaum