These volumes, Cytolytic Lymphocytes and Complement: Effectors of the Immune System, originate from the realization that pathways of recognition and killings of foreign targets follow similar routes in the humoral and cellular part of the immune system. In particular, the homology of immunoglobins with the T-cell-MHC-antigen receptor at the beginning of the recognition sequence and the homology of complement component C9 with lymphocyte perforin 1 (P1) as pore formers at the end of the effector sequence are striking examples.
Table of Contents
Cytolytic Mechanism � Killer Lymphocytes 15. Properties and Function of Cytolytic Lymphocyte Granules 16. Properties of Transmembrane Channels Induced by Cytolytic Lymphocytes 17. The Role of Nuclear Damage in Lysis of target Cells by Cytotoxic T. Soluble Cytotoxic Factors Produced by Lymphocytes 18. Production and Function of Lymphotoxin Secreted by Cytolytic T Cell 19. Tumor Necrosis Factor/Cachectin. 20 Natural Killer Cytotoxic Factor NKCF as Mediator in the Lytic Pathway of NK Cell Mediated Cytoxicity 21. Tumor Necrosis Factors and Therapeutic Applications 22. Antibody Conjugates with Cobra Venom Factor as Selective Agents for Tumor Cell Killing 23. A Function for NK Cells in Acute Bone Marrow Allograft Rejection 24. Cytolytic T Lymphocyte Clones in Anti-Viral Immunity- Effector Function In Vivo and Mechanism of Action 25. Interleukin-2 Activated Cytoxic Lymphocytes LAK Cells as Antigen Nonspecific Amplifiers of the Immune Response- General Characteristics and Considerations for Cancer Therapy 26. The Contribution of Natural Killer and T-Cells to the Lymphokine Activated Killer Cell Phenomen 27. Targeting for T-Lymphocyte-Mediated Lysis by Hybrid Antibodies 28. Longterm Growth and Expansion of I12 Activated NK-Cells for Cancer Therapy