Details all clinically relevant cytokines, including interleukins, interferons, enkephalins, and endorphins Explores cytokine-hormone interactions and the clinical implications of those interactions on the immune, endocrine, and central nervous systems Reviews the documented behavior effects of cytokine activityConsiders genetic predispositions toward cytokine activity Discusses the role of interferon in health and diseaseExamines the clinical relevance of opioid-induced immonosuppression
Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness.
The first edition of Cytokines: Stress and Immunity pointed out that the immune system does not stand alone, but is profoundly affected by other organ systems, especially the central nervous and the neuroendocrine systems, with cytokines being the common tool of communication. This edition continues on the trailblazing path of the original to once again present current research that informs our evolving understanding of how cytokines function and the clinical implications of cytokine activity.
Completely rewritten by the top authorities in their fields, this volume includes 16 entirely new chapters, which document dramatic new developments. It provides a comprehensive overview of the role of cytokines in the neuroendocrine and immune systems, while also addressing the interactions between these systems. It examines cytokine activity and clinical implications from a number of perspectives, including those of immunology, pharmacology, oncology, endocrinology, and psychiatry. Researchers involved with the most specific aspects of cell signaling as well clinicians dealing with the effects of immunosuppression-related diseases will find a wealth of interesting and instantly applicable information.
This new edition begins with an extended dedication and tribute to the late Robert A. Good, the father of modern immunology. It documents the life and groundbreaking achievements of Dr. Good who served as an editor for both the former and current editions of this work.
Table of Contents
Behavioral Effects of Cytokines: A Psychiatrist's Perspective; Ziad Kronfol
Worried to Death? Stress, Worry, and Immune Dysregulation
in Health and HIV; Suzanne C. Segerstrom and Margaret E. Kemeny
Psychological Stress and Its Relationship to Cytokines
and Inflammatory Diseases; Rama Murali, Margaret D. Hanson, and Edith Chen
Role of Cytokines in Depression; Ghanshyam N. Pandey and Yogesh Dwivedi
Loneliness, Dysphoria, Stress, and Immunity: A Role for Cytokines; Louise C. Hawkley, Jos A. Bosch, Christopher G. Engeland, Phillip T. Marucha, and John T. Cacioppo
Stress, Cytokines, and Peripheral Analgesia; Peter John Cabot
Alexithymia, Stress, and Immunity; Olivier Guilbaud, Maurice Corcos, and Philippe Jeammet
Roles of Mu-Opioid Receptor and Endogenous Opiates in Stress-Induced Immunosuppression; Jennifer Kelschenbach, Horace H. Loh, and Sabita Roy
Stress, Opioid Peptides, and Immune Response; Javier Puente, Marion E. Wolf, M. Antonieta Valenzuela, and Aron D. Mosnaim
Met-Enkephalin in Oxidative Stress; Tihomir Balog, Sandra Soboc? anec, Vis?nja Sc?verko, Helena Haberstock-Debic´ and Tatjana Marotti
Chronic Stress Induces Death of Lymphocytes; Erwei Sun, Lixin Wei, Arthur I. Roberts, Catherine Liu, and Yufang Shi
Interleukin- and the Hypothalamic-Pituitary-Adrenal Axis; Eric M. Smith, Huolin Tu, and Thomas K. Hughes, Jr.
Cytokines, Stress, and Depression; Adrian J. Dunn
Immunoconversion in Acute Phase Response; Istvan Berczi, Andres Quintanar-Stephano, and Kalman Kovacs
Interferon in Health and Disease; Nachum Dafny, Pamela B. Yang, and Stanley A. Brod
Neuropeptide Precursor Processing in Immunocytes:
Involvement in Neuroimmune Communication; Robert Day and Michel Salzet
Clinical Relevance of Opioid-Induced Immunosuppression: Are All Drugs Similar? Paola Sacerdote, Sivia Franchi, and Cataldo Martucci
Human Retroviruses and the Cytokine Network; Massimo Alfano and Guido Poli
Psychiatric Toxicity of Interferon-?: A Model for Understanding the Etiology of Major Depression and Chronic Fatigue Syndrome? Gopinath Ranjith and Carmine Pariante
Role of Genetic Predisposition, Cytokines, and Neuroendocrine
Response in Development of Thyroid Autoimmunity; Antonio Martocchia and Paolo Falaschi
Gender Differences, Stress, and Immunity; Nicholas P. Plotnikoff and Robert E. Faith