Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel methods of discovery for more potent and specific blocking agents.
Investigates the pathogenic role of cytokines and the potential of cytokine inhibitors as anti-inflammatory, anticancer, antiviral agents!
Written by 25 recognized experts revealing recent breakthroughs in research, Cytokine Inhibitors
illustrates cases of naturally produced or in vitro engineered polypeptide cytokine blocking agents
describes all possible approaches to cytokine inhibitors, including monoclonal antibodies, soluble receptors, engineered mutant cytokines, and small-molecular-weight receptor antagonists and signaling inhibitors
clearly explains the homeostatic function of cytokine inhibition and verifies therapeutic approaches effecting natural responses in organisms
discusses the results of clinical trials and therapeutic applications of first-generation recombinant receptor antagonists, such as the potential of tumor necrosis factor antagonists as prominent tools in the therapy of chronic inflammatory conditions
concentrates on the clinical development of second-generation small-molecular-weight, orally bioavailable cytokine inhibitors
reviews the improved understanding of intracellular signaling pathways, the structural determinants responsible for cytokine-receptor interaction
lists the three-dimensional structure, relevant receptors, and intracellular tyrosine kinases of cytokines
and much more!
Containing over 1400 references as well as tables and drawings, Cytokine Inhibitors serves as an exemplary reference for basic and clinical immunologists; allergists; biochemists; pathologists, hematologists; experimental, cell, and molecular biologists; rheumatologists; infectious disease specialists; medicinal chemists; and medical school and upper-level undergraduate and graduate students in these disciplines.
Table of Contents
Importance of the Interleukin-1 -Converting Enzyme in Disease Mediated by the Proinflammatory Cytokines IL-1 and IL-18
…up-to-date and detailed...[a] comprehensive reference.
"-Journal of Investigational Allergology and Clinical Immunology
"…a perfect justification for a multiauthored book….
…useful to medicinal chemists who are new to the field, or those who want to look at a broader range of cytokines.
"-Journal of Medicinal Chemistry