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Critical Reviews in Combinatorial Chemistry


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Analytical Methods in Combinatorial Chemistry

Analytical Methods in Combinatorial Chemistry

2nd Edition

Bing Yan, Bin Zhang
June 14, 2017

Since the publication of the benchmark first edition of this book, chemical library and combinatorial chemistry methods have developed into mature technologies. There have also been significant shifts in emphasis in combinatorial synthesis. Reflecting the growth in the field and the heightened...

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

1st Edition

Taosheng Chen
December 21, 2009

The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to...

High-Throughput Analysis in the Pharmaceutical Industry

High-Throughput Analysis in the Pharmaceutical Industry

1st Edition

Perry G. Wang
August 20, 2008

The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a...

High-Throughput Lead Optimization in Drug Discovery

High-Throughput Lead Optimization in Drug Discovery

1st Edition

Tushar Kshirsagar
March 04, 2008

A Single Source on Parallel Synthesis for Lead Optimization The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library...

Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials

Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials

1st Edition

Radislav A. Potyrailo, Wilhelm F. Maier
July 19, 2006

The development of parallel synthesis and high-throughput characterization tools offer scientists a time-efficient and cost-effective solution for accelerating traditional synthesis processes and developing the structure-property relationships of multiple materials under variable conditions....

Combinatorial Synthesis of Natural Product-Based Libraries

Combinatorial Synthesis of Natural Product-Based Libraries

1st Edition

Armen M. Boldi
May 16, 2006

Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe...

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