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Controlled Release Dosage Form Design offers the tools needed to eliminate trial-and error and wasted time and money in controlled release dosage form design! How is this accomplished? By helping the reader UNDERSTAND controlled release technology more quantitatively and mechanistically, thereby creating a "visual" overall picture of the technology.
Controlled Release Dosage Form Design is an invaluable tool for all students and professionals in pharmaceutics, chemistry, chemical engineering, biology/biotechnology and medicine. If you are engaged or interested in the development of dosage forms, you will find this book invaluable. You will learn to look at controlled release dosage forms INTERRELATED to each other, rather than piece by piece. You will learn to KNOW how the mechanistic principles which can be applied in dosage forms. Work faster, smarter and with more intuition!
Table of Contents
Introduction Conventional vs. Controlled Release Advantages and Disadvantages Pharmacokinetic Considerations of CRDF Polymers as Drug Carriers Classification of CRDFs Monolithic Matrix Controlled Systems Dissolved Drugs Dispersed Drugs Drug-dissolution/diffusion Controlled Systems Membrane Controlled Systems Constant Activity Reservoir Non-Constant Activity Reservoir Release of a Drug from a Membrane Reservoir into a Finite Volume Unsteady State Analysis (Time-lag & Burst-effect) Drug Release from Multi-layer Membrane Devices Drug Release from Membrane-matrix Systems Membrane Transport with Bio-conversion Swelling Controlled Systems Mathematical Expression Hydrogel Systems Polymer Dissolution Controlled Systems Classification of Polymer Degradation and Erosion Heterogeneous Erosion Homogeneous Erosion Acid Catalyzed Degradation Autocatalyzed Degradation Erosion/Drug Diffusion Controlled Swelling/Erosion Controlled Preparation of Biodegradable Microparticles Gradient Matrix Systems Mathematical Expression Tablets Hydrogel Beads Granules Megaporous Ion Exchange Resin Systems Exchange Process and Equilibrium Ion Exchange Materials Drug Release from Commercial Ion Exchange Resins Highly Swellable Polyelectrolyte Erodible Polyelectrolyte Principle of Diffusion in the Ion Exchange Resin Matrix (Shrinking-core Model) Drug Release in a Limited Volume Osmotically Controlled Systems Osmosis Elementary Osmotic Pump (OROS) Solubility Modulated OROS Microporous Osmotic Pump Push-Pull Geometrically Modified Systems Pie Shape, Perforated Coated, Donut (Coated/Uncoated), and Multi-hole Frustum and Hemisphere Multi-layer Tablet and Cylinder Systems Other Systems Hydrodynamically Balanced Systems Oral Time-controlled (Pulsatile) Release Systems Pharmacokinetic Considerations of CRDF Design One-compartment Model Two-compartment Model with Zero-order Release Kinetics Pharmacokinetics on Transdermal Delivery Systems In-vitro/In-vivo Correlation
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CHOICE – Outstanding Academic Title – Award Winner
CHOICE – 2018 Outstanding Academic Title – Award Winner
Shingo Research and Professional Publication Award Winner
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