Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities.
Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies.
Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.
Table of Contents
Automation in Combinatorial Chemistry. Computational Aspects of Combinatorial Chemistry. High Throughput Combinatorial Methods for Heterogeneous Catalysts Design and Development. Biological Libraries. Peptide Display Libraries: Design and Construction. Making and Selecting from Phage Antibody Libraries. Biopanning. Oligonucleotide Library Preparation and Screening. Application of Selex Technology to Drug and Diagnostic Development. Combinatorial Proteomic. A Combinatorial Approach to Gene Expression Analysis: DNA Microarrays. Economics of Combinatorial Chemistry and Combinatorial Technologies.
"The authors have been quite successful in their efforts to provide a guide to scientists involved in the field of drug discovery with little-or-no knowledge of combinatorial chemistry…this overall instruction guide is a valuable companion to scientists involved in combinatorial work. …The authors have succeeded in their endeavor by appraising several production methods, and comparing the costs for generating an entity through various research and development techniques."
-Yesh P. Sachdeva, Synthesis, 2006