First published in 1989: State-of-the-art information on the topic of clinical thrombosis, including an introductory portion dealing with the principles of hemostasis and the pathogenesis of thrombosis, is presented in this text. The use of thrombolytic therapy in acute myocardial infarction is discussed. Other significant advances, such as the identification and understanding of the risk factors contributing to thrombosis such as Protein C and S deficiency, lupus anticoagulants, immune heparin-induced thrombocytopenia, new diagnostic techniques and newer modalities of therapy, are described. Clinical and pathophysiologic features of thrombosis disorders and special situations involving multiple organs are covered. This book also clarifies and updates the usefulness of the various diagnostic techniques.
Table of Contents
Thrombosis: A Multidisciplinary Approach. PATHOPHYSIOLOGY OF HEMOSTASIS. Initial Phase of Hemostasis. Physiology and Basic Investigation of Blood Coagulation. Fibrinolytic System. Pathogenesis of Thrombosis. Clinical Hemorheology. THROMBOEMBOLIC DISORDERS. Venous Thrombosis. Practical Approaches for Prevention of Venous Thrombosis. Postphlebitic Disease. Acute Pulmonary Embolism. Cerebral Vascular Disease. Coronary Artery Disease: Role of Antithrombotic Therapy. Peripheral Arterial Thromboembolic Hormonal Treatments and Thrombosis. Thromboembolic Disease in the Obstetric Patient. Thrombosis in Children. Thromboembolism and Cancer. Special Thromboembolic Problems in the Neurosurgical Patient. Disseminated Intravascular Coagulation. Thrombotic Microangiopathy. Lupus Anticoagulants. DIAGNOSTIC ASPECTS OF THROMBOEMBOLISM. Laboratory Diagnosis of Thrombosis. Laboratory Diagnosis of Acquired Thrombophilic States: Detection of Markers of Activation of Primary Hemostasis and of Blood Coagulation. Imaging of Thrombosis. Noninvasive Diagnostic Procedures. PHARMACOLOGIC AND THERAPEUTIC ASPECTS OF THROMBOEMBOLISM. Anticoagulant Therapy. Antiplatelet Therapy. Thrombolytic Therapy. Miscellaneous: Dextran, Dermatan Sulfate, Low Molecular Weight Heparin, Heparinoid (Org 10172), Pentosan Polysulfate (SP54), Defibrinating Agents (Ancrod and Reptilase). Surgical Treatment of Venous Thromboembolism.