Written by over 50 internationally distinguished experts, 30 more than the first edition, and contains nine new chapters!
Continuing in the esteemed tradition and heralded success of the first edition, Chronic Lymphoid Leukemias, Second Edition offers a full overview of chronic lymphocytic leukemia (CLL) from multiple perspectives-covering all major developments since the previous edition was published eight years ago.
Chronicling the complete history and variations of CLL-type leukemia, the Second Edition
reviews the origin, nature, and molecular differences between B-CLL and T-CLL/PLL leukemias
analyzes core constituents of apoptosis and causes for dysregulation of programmed cell death (PCD) in B-CLL
examines recent research on the role cytokines and regulatory molecules may play in cross-cell communication
profiles commonly used vectors for somatic gene therapy, as well as the latest advances in genetic engineering and vector design and production
utilizes up-to-the-minute techniques such as fluorescence in-situ hybridization (FISH) and comparative genomic hybridization (CGH) to detect genetic abnormalities and aberrations
explores current measures of supportive care with splenectomy, cytokine proteins, and intravenous immunoglobulin applications
identifies how to manage infectious and psychiatric complications in patients with CLL
and much more!
Provides contemporary results on the efficacy of nucleoside analog combinations such as ara-C with fludarabine and cladribine and on the emerging nucleosides nelarabine and clofarabine!
Copiously supplemented with over 2500 literature references-1000 more than the first edition-Chronic Lymphoid Leukemias, Second Edition fulfills the reference needs of oncologists, hematologists, immunologists, pathologists, infectious disease specialists, internists, molecular biologists, and medical school students in these disciplines.
Table of Contents
History of Chronic Lymphocytic Leukemia
Kanti R. Rai and Tarun Wasil
Molecular Biology of Chronic Lymphocytic Leukemia
Florencia Bullrich and Carlo M. Croce
Chronic Lymphocytic Leukemia: Epidemiological, Familial, and Genetic Aspects
Maria T. Sgambati, Martha S. Linet, and Susan S. Devesa
The Origin and Nature of the Chronic Lymphocytic Leukemia Lymphocyte
Paolo Ghia and Federico Caligaris-Cappio
Immunoglobulin Variable Region Gene Characteristics and Surface Membrane Phenotype Define B-CLL Subgroups with Distinct Clinical Courses
Nicholas Chiorazzi and Manlio Ferrarini
Apoptosis Dysregulation in Chronic Lymphocytic Leukemia
John C. Reed and Shinichi Kitada
Cytokines and Regulatory Molecules in the Pathogenesis and Clinical Course of B-Cell Chronic Lymphocytic Leukemia
Enrica Orsini and Robin Foa
Randomized Trials: What Do They Teach us About Chronic Lymphocytic Leukemia Treatment?
Genetic Approaches to the Therapy of Chronic Lymphocytic Leukemia
Thomas J. Kipps
Combination Strategies for Purine Nucleoside Analogs
Varsha Gandhi and William Plunkett
Differential Diagnosis of the Chronic B-Cell Lymphoid Leukemias
Randy D. Gascoyne
Prognostic Factors in Chronic Lymphocytic Leukemia
Initial Approach to the Patient with Chronic Lymphocytic Leukemia
Bruce D. Cheson
Management of the Patient with Relapsed or Refractory Chronic Lymphocytic Leukemia
Deborah A. Thomas, Susan M. O'Brien, and Michael J. Keating
The Use of Therapeutic Monoclonal Antibodies in Chronic Lymphocytic Leukemia
Martin J. S. Dyer and Anders Österborg
Genomic Aberrations in B-Cell Chronic Lymphocytic Leukemia
Stephan Stilgenbauer, Peter Lichter, and Hartmut Döhner
Developing Risk-Adapted Treatment Strategies for Chronic Lymphocytic Leukemia
High-Dose Therapy and Stem Cell Support in Chronic Lymphocytic Leukemia
Angela M. Krackhardt and John G. Gribben
Finding New Therapies for Patients with Chronic Lymphocytic Leukemia
John C. Byrd and Michael R. Grever
Autoimmune Disease and Its Management in Chronic Lymphocytic Leukemia
John Seymour and Janine Campbell
Supportive Care in Chronic Lymphocytic Leukemia
Farhad Ravandi, Michael J. Keating, and Susan M. O'Brien
Infections in Patients with Chronic Lymphocytic Leukemia: Pathogenesis, Spectrum, and Therapeutic Approaches
Vicki A. Morrison
Prolymphocytic Leukemia of B- and T-Cell Types: Biology and Therapy
Estella Matutes, Vasantha Brito-Babapulle, Claire Dearden, M. R. Yullie, and Daniel Catovsky
Chronic T-Cell and NK-Cell Leukemias
Edgar G. Miranda and Thomas P. Loughran, Jr.
Current Concepts in the Management of Hairy Cell Leukemia
Martin S. Tallman, Mark A. Hoffman, and LoAnn C. Peterson
Psychological Aspects of Chronic Lymphoid Leukemia
Jahandar Saifollahi, Marjaneh Rouhani, Andrew J. Roth, and Jimmie C. Holland
Praise for the first edition…
An informative, up-to-date, well-referenced, and user-friendly text.
With an illustrious cadre of authors, Cheson has crafted together state-of-the-art reviews...
…a valuable addition to reference libraries…this compendium meets the need for an excellent reference text on CLL."-Hematologic Pathology
"…[an] important book.
…well written and edited….the editor deserves praise for…fostering a general sense of continuity."-The New England Journal of Medicine
"…of great value to hematologists and oncologists….readers will learn a lot about the recent progress in CLL."-International Journal of Hematology
"…a valuable contribution in bringing together disparate aspects of biology and clinical management of CLL….a useful compendium."-Australian Cancer Society
"…should be ready by everyone taking care of pediatric patients with chronic lymphocytic leukemia (CLL)…up-to-date….an excellent, comprehensive review of the current treatment modalities….
…the best review of CLL and related diseases currently available.
"-Annals of Oncology