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Cholesterol in Membrane Models provides the most recent summary available of basic molecular models and experiments in models of biological membranes. The book introduces the cell biology of cholesterol and covers the modeling of cholesterol in model membranes by the mean field and Monte Carlo theoretical methods. The experimental movement of cholesterol into model membranes and phase diagrams of cholesterol in these membranes by nuclear magnetic resonance and by thermal techniques using different lipid chain lengths are discussed. Light and electron microscopy that explore the spatial distribution of cholesterol in the model membrane are covered. The book also examines the use of infrared/Raman and neutron spectroscopy.
Cholesterol in Membrane Models is an excellent learning resource, research tool, and reference for a wide range of experimental and theoretical scientists, including cellular biologists, biophysicists, biochemists, and molecular modelers.
Table of Contents
The Biophysics and Cell Biology of Cholesterol: An Hypothesis for the Essential Role of Cholesterol in Mammalian Cells (Philip L. Yeagle). Neutron Scattering as a Tool to Probe the Effect of Cholesterol on Phase Separation, Structure Formation, and Lipid/Protein Interaction in Artificial Membranes (Thomas M. Bayerl and Erich Sackmann). Kinetics of Cholesterol Movement between Donor and Acceptor Bilayer Membranes (Robert Bittman). The Molecular Dynamics, Orientational Order and the Thermodynamic Phase Equilibria of Cholesterol/Phosphatidylcholine Mixtures (James H. Davis). Cholesterol/Phospholipid Interactions Studied by Differential Scanning Calorimetry: Effect of Acyl Chain Length and Role of the C(17) Sterol Side Group (Leonard Finegold and Michael A. Singer). Visualization of Cholesterol Domains in Model Membranes (Sek Wen Hui). Vibrational Spectroscopy of Cholesterol-Lipid Interactions (Timothy J. O'Leary). Lipid-Cholesterol Phase Diagrams: Theoretical and Numerical Aspects (H. Larry Scott). Theoretical Studies of the Phase Behavior of Lipid Bilayers Containing Cholesterol (Martin J. Zuckermann, John H. Ipsen, and Ole G. Mouritsen).
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CHOICE – Outstanding Academic Title – Award Winner
CHOICE – 2018 Outstanding Academic Title – Award Winner
Shingo Research and Professional Publication Award Winner
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