Reveals important new results from clinical trials conducted in Scandinavia, Scotland, Australia, Canada, and the United States.
This timely reference reviews the vast body of clinical trial evidence supporting the once controversial view that high levels of serum cholesterol are a major risk factor in coronary heart disease (CHD). The studies presented in Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence promote cholesterol reduction as a highly successful means of preventing heart disease in various populations.
Investigates past, current, and upcoming controlled clinical trials of cholesterol-reduction therapies, comparing effects of statins and bile acid sequestrants to triglyceride-lowering drugs and antioxidants.
Written by more than 25 distinguished international researchers, Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence
highlights historical studies of dietary trials designed to reduce CHD
covers tests of HMG CoA reductase inhibitors for patients with and without CHD
illuminates CHD risk factors such as diabetes, hypertension, obesity, and smoking
explores blood levels of homocysteine and lipoprotein(a) and other recently identified CHD risk factors
reviews metabolism of lipoproteins expressed in high (HDL) and low (LDL) density lipoprotein cholesterol
Containing over 700 instructive tables, drawings, photographs, and bibliographic citations, Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence is a must-read resource for cardiologists, pharmacologists, and upper-level undergraduate, graduate, and medical school students in these disciplines.
Table of Contents
Cholesterol-Lowering Clinical Trials: A Historical Perspective
Scott M. Grundy
Scandinavian Simvastatin Survival Study (4S)
Terje R. Pedersen
The Cholesterol and Recurrent Events Trial (CARE): The Effect of Pravastatin on Coronary Events After Myocardial Infarction in Patients with Average Cholesterol Levels
Frank M. Sacks, Marc A. Pfeffer, Lemuel A. Moyé, C. Morton Hawkins, Barry R. Davis, Jean L. Rouleau, Thomas G. Cole, and Eugene Braunwald
Lessons from the West of Scotland Coronary Prevention Study (WOSCOPS)
James Shepherd and Allan Gaw
Program on the Surgical Control of the Hyperlipidemias (POSCH) Trial: A Pivotal 25-Year Study
The Air Force/Texas Atherosclerosis Prevention Study (AFCAPS/TexCAPS): Primary Prevention of Acute Major Coronary Events in Women and Men with Average Cholesterol
Stephen Weis, Michael Clearfield, Lt. Col. John R. Downs, and Antonio M. Gotto, Jr.
Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) Study: Clinical Implications for Cardiovascular Practice
Andrew M. Tonkin and David Hunt
Angiographic Results of Lipid-Lowering Trials: A Systematic Review and Meta-Analysis
Cheryl L. Holmes, Michael Schulzer, and G. B. John Mancini
Biochemical Correlates of Plaque Progression and Coronary Events
Melissa Ferraro-Borgida and David Waters
Lipid Therapy to Stabilize the Vulnerable Atherosclerotic Plaque: New Insights into the Prevention of Cardiovascular Events
B. Greg Brown and Xue-Qiao Zhao
Cholesterol-Lowering Trials with Carotid Ultrasonographic Outcomes
Robert P. Byington
Cholesterol Lowering Reduces Mortality: The Statins
David J. Gordon
From the Foreword…
This volume is intended to provide busy physicians with the information they need to make the best possible decisions for their patients.
So much information is given to practicing physicians nowadays that it often makes their job more difficult. This authoritative compendium can make it easier and, in so doing, will greatly benefit patients.
"-Claude Lenfant, M.D.
"…an excellent work.
"…timely…up-to-date…a valuable asset for researchers, Ph.D. students and clinicians alike.
"…comprehensively covers many aspects of microbial plant endophytes….
…everyone involved in this field of research should find something of interest in the volume.